Effects of Dietary Induced Weight Loss on Exercise-Induced Bronchoconstriction in Overweight and Obese Children

Janneke C. van Leeuwen*, Mira Hoogstrate, Eric J. Duiverman, Boony J. Thio

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    32 Citaten (Scopus)


    RationalePrevious studies showed that obesity in asthmatic children is associated with more severe exercise-induced bronchoconstriction (EIB), compared with non-obese asthmatic children. This study investigates the effect of weight loss on EIB in overweight and obese asthmatic children.

    MethodsIn this intervention study, children aged 8-18 years with EIB and moderate to severe overweight, followed a diet based on healthy daily intake for 6 weeks. Before and after the diet period they underwent an exercise challenge test in cold air. Primary outcome was change in exercise-induced fall in FEV1 and relation between weight loss and EIB. Secondary outcomes were changes in recovery of FEV1 (area under the curve; AUC), fraction of exhaled nitric oxide (FeNO) and scores of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) and Asthma Control Questionnaire (ACQ).

    ResultsTwenty children completed the study. After the diet period, weight, and body mass index (BMI) were significantly reduced (changes respectively -2.6% and -1.5kg/m(2), P

    ConclusionsDietary induced weight loss in overweight and obese asthmatic children leads to significant reduction in severity of EIB and improvement of the quality of life. The reduction in BMI z-score is significantly related to the improvement of EIB. Pediatr Pulmonol. 2014; 49:1155-1161. (c) 2013 Wiley Periodicals, Inc.

    Originele taal-2English
    Pagina's (van-tot)1155-1159
    Aantal pagina's5
    TijdschriftPediatric Pulmonology
    Nummer van het tijdschrift12
    StatusPublished - dec-2014

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