Effects of early life stress on biochemical indicators of the dopaminergic system: A 3 level meta-analysis of rodent studies

V. Bonapersona*, M. Joels, R. A. Sarabdjitsingh

*Bijbehorende auteur voor dit werk

    Onderzoeksoutputpeer review

    24 Citaten (Scopus)
    43 Downloads (Pure)

    Samenvatting

    Adverse early life events are a well-established risk factor for the precipitation of behavioral disorders characterized by anomalies in the dopaminergic system, such as schizophrenia and addiction. The correlation between early life conditions and the dopaminergic system has been causally investigated in more than 90 rodent publications. Here, we tested the validity of the hypothesis that early life stress (ELS) alters dopamine signaling by performing an extensive 3-level mixed effect meta-analysis. We included several ELS models and biochemical indicators of the dopaminergic system in a variety of brain areas, for a total of 1009 comparisons. Contrary to our expectations, only a few comparisons displayed a significant effect. Specifically, the striatal area was the most vulnerable, displaying decreased dopamine precursor and increased metabolites after ELS. To make all data openly accessible, we created MaDEapp (https://osf.io/w25m4/), a tool to explore data of the meta-analysis with the intent to guide future (pre)clinical research and allow power calculations. All in all, ELS induces a few yet robust changes on biochemical indicators of the dopaminergic system.

    Originele taal-2English
    Pagina's (van-tot)1-16
    Aantal pagina's16
    TijdschriftNeuroscience and Biobehavioral Reviews
    Volume95
    DOI's
    StatusPublished - dec.-2018

    Citeer dit