Effects of GLP-1 and 2,5-Anhydro-D-Mannitol on Insulin Secretion and Plasma Glucose in Mice

B. Ahrén, S. Lindskog, G. van Dijk, A.J.W. Scheurink, A.B. Steffens

OnderzoeksoutputAcademicpeer review

9 Citaten (Scopus)
254 Downloads (Pure)


The truncated glucagon-like peptide-1 (GLP-1((7.36))amide or GLP-1) stimulates insulin secretion, enhances glucose elimination and is of potential interest in diabetes treatment. We studied the hypoglycemic action of GLP-1 in normal mice when given alone or together with the fructose analogue, 2,5-anhydro-D-mannitol (2,5-AM), which inhibits glycogenolysis and gluconeogenesis. GLP-1 (32 nmol/kg iv) lowered plasma glucose levels after 25 min to 4.6+/-0.2 mmol/l compared with 7.3+/-0.4 mmol/l in controls (P

Originele taal-2English
Pagina's (van-tot)583-594
Aantal pagina's12
TijdschriftEndocrine Research
Nummer van het tijdschrift3
StatusPublished - 1995

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