Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty

Anton H. Hosman; Henny C. van der Mei; Sjoerd K. Bulstra; Henk J. Busscher; Danielle Neut

doi:10.3109/17453674.2010.519169

Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty

Anton H. Hosman, Henny C. van der Mei, Sjoerd K. Bulstra, Henk J. Busscher, Danielle Neut^*

^*Corresponding author voor dit werk

Public Health Research

Onderzoeksoutput › peer review

66 Citaten (Scopus)

267 Downloads (Pure)

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Methods We reviewed the available literature on the influence of degradation products of MOM bearings in total hip arthroplasties on infection risk.

Results Wear products were found to influence the risk of infection by hampering the immune system, by inhibiting or accelerating bacterial growth, and by a possible antibiotic resistance and heavy metal co-selection mechanism.

Interpretation Whether or not the combined effects of MOM wear products make MOM bearings less or more prone to infection requires investigation in the near future.

Originele taal-2	English
Pagina's (van-tot)	526-534
Aantal pagina's	9
Tijdschrift	Acta Orthopaedica
Volume	81
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.3109/17453674.2010.519169
Status	Published - okt.-2010

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10.3109/17453674.2010.519169Licentie: CC BY-NC

Effects of metal-on-metalFinal publisher's version, 595 KBLicentie: CC BY-NC

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@article{6c36fa2e1a6f47e5b4d751da5724035f,

title = "Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty",

abstract = "Methods We reviewed the available literature on the influence of degradation products of MOM bearings in total hip arthroplasties on infection risk.Results Wear products were found to influence the risk of infection by hampering the immune system, by inhibiting or accelerating bacterial growth, and by a possible antibiotic resistance and heavy metal co-selection mechanism.Interpretation Whether or not the combined effects of MOM wear products make MOM bearings less or more prone to infection requires investigation in the near future.",

keywords = "FOREIGN-BODY INFECTION, COBALT-CHROME ALLOY, IN-VITRO, FOLLOW-UP, RESURFACING ARTHROPLASTY, ION RELEASE, DNA-DAMAGE, ALCALIGENES-EUTROPHUS, ARTICULATING SURFACES, QUANTITATIVE-ANALYSIS",

author = "Hosman, {Anton H.} and {van der Mei}, {Henny C.} and Bulstra, {Sjoerd K.} and Busscher, {Henk J.} and Danielle Neut",

year = "2010",

month = oct,

doi = "10.3109/17453674.2010.519169",

language = "English",

volume = "81",

pages = "526--534",

journal = "Acta Orthopaedica",

issn = "1745-3674",

publisher = "Taylor & Francis Ltd",

number = "5",

}

TY - JOUR

T1 - Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty

AU - Hosman, Anton H.

AU - van der Mei, Henny C.

AU - Bulstra, Sjoerd K.

AU - Busscher, Henk J.

AU - Neut, Danielle

PY - 2010/10

Y1 - 2010/10

N2 - Methods We reviewed the available literature on the influence of degradation products of MOM bearings in total hip arthroplasties on infection risk.Results Wear products were found to influence the risk of infection by hampering the immune system, by inhibiting or accelerating bacterial growth, and by a possible antibiotic resistance and heavy metal co-selection mechanism.Interpretation Whether or not the combined effects of MOM wear products make MOM bearings less or more prone to infection requires investigation in the near future.

AB - Methods We reviewed the available literature on the influence of degradation products of MOM bearings in total hip arthroplasties on infection risk.Results Wear products were found to influence the risk of infection by hampering the immune system, by inhibiting or accelerating bacterial growth, and by a possible antibiotic resistance and heavy metal co-selection mechanism.Interpretation Whether or not the combined effects of MOM wear products make MOM bearings less or more prone to infection requires investigation in the near future.

KW - FOREIGN-BODY INFECTION

KW - COBALT-CHROME ALLOY

KW - IN-VITRO

KW - FOLLOW-UP

KW - RESURFACING ARTHROPLASTY

KW - ION RELEASE

KW - DNA-DAMAGE

KW - ALCALIGENES-EUTROPHUS

KW - ARTICULATING SURFACES

KW - QUANTITATIVE-ANALYSIS

U2 - 10.3109/17453674.2010.519169

DO - 10.3109/17453674.2010.519169

M3 - Review article

C2 - 20860450

SN - 1745-3674

VL - 81

SP - 526

EP - 534

JO - Acta Orthopaedica

JF - Acta Orthopaedica

IS - 5

ER -

Effects of metal-on-metal wear on the host immune system and infection in hip arthroplasty

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