Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition

M Kriege; CTM Brekelmans; C Boetes; PE Besnard; HM Zonderland; IM Obdeijn; RA Manoliu; T Kok; H Peterse; MMA Tilanus-Linthorst; SH Muller; S Meijer; JC Oosterwijk; LVAM Beex; RAEM Tollenaar; HJ de Koning; EJT Rutgers; JGM Klijn; Magnetic Resonance Imaging Screeni

Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition

M Kriege, CTM Brekelmans, C Boetes, PE Besnard, HM Zonderland, IM Obdeijn, RA Manoliu, T Kok, H Peterse, MMA Tilanus-Linthorst, SH Muller, S Meijer, JC Oosterwijk, LVAM Beex, RAEM Tollenaar, HJ de Koning, EJT Rutgers, JGM Klijn^*, Magnetic Resonance Imaging Screeni

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

1444 Citaten (Scopus)

Samenvatting

BACKGROUND:

The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to breast cancer is currently unproven. We compared the efficacy of magnetic resonance imaging (MRI) with that of mammography for screening in this group of high-risk women.

METHODS:

Women who had a cumulative lifetime risk of breast cancer of 15 percent or more were screened every six months with a clinical breast examination and once a year by mammography and MRI, with independent readings. The characteristics of the cancers that were detected were compared with the characteristics of those in two different age-matched control groups.

RESULTS:

We screened 1909 eligible women, including 358 carriers of germ-line mutations. Within a median follow-up period of 2.9 years, 51 tumors (44 invasive cancers, 6 ductal carcinomas in situ, and 1 lymphoma) and 1 lobular carcinoma in situ were detected. The sensitivity of clinical breast examination, mammography, and MRI for detecting invasive breast cancer was 17.9 percent, 33.3 percent, and 79.5 percent, respectively, and the specificity was 98.1 percent, 95.0 percent, and 89.8 percent, respectively. The overall discriminating capacity of MRI was significantly better than that of mammography (P

CONCLUSIONS:

MRI appears to be more sensitive than mammography in detecting tumors in women with an inherited susceptibility to breast cancer.

Originele taal-2	English
Pagina's (van-tot)	427-437
Aantal pagina's	11
Tijdschrift	New England Journal of Medicine
Volume	351
Nummer van het tijdschrift	5
Status	Published - 29-jul.-2004

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Kriege, M., Brekelmans, CTM., Boetes, C., Besnard, PE., Zonderland, HM., Obdeijn, IM., Manoliu, RA., Kok, T., Peterse, H., Tilanus-Linthorst, MMA., Muller, SH., Meijer, S., Oosterwijk, JC., Beex, LVAM., Tollenaar, RAEM., de Koning, HJ., Rutgers, EJT., Klijn, JGM., & Magnetic Resonance Imaging Screeni (2004). Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. New England Journal of Medicine, 351(5), 427-437.

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title = "Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition",

abstract = "BACKGROUND:The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to breast cancer is currently unproven. We compared the efficacy of magnetic resonance imaging (MRI) with that of mammography for screening in this group of high-risk women.METHODS:Women who had a cumulative lifetime risk of breast cancer of 15 percent or more were screened every six months with a clinical breast examination and once a year by mammography and MRI, with independent readings. The characteristics of the cancers that were detected were compared with the characteristics of those in two different age-matched control groups.RESULTS:We screened 1909 eligible women, including 358 carriers of germ-line mutations. Within a median follow-up period of 2.9 years, 51 tumors (44 invasive cancers, 6 ductal carcinomas in situ, and 1 lymphoma) and 1 lobular carcinoma in situ were detected. The sensitivity of clinical breast examination, mammography, and MRI for detecting invasive breast cancer was 17.9 percent, 33.3 percent, and 79.5 percent, respectively, and the specificity was 98.1 percent, 95.0 percent, and 89.8 percent, respectively. The overall discriminating capacity of MRI was significantly better than that of mammography (PCONCLUSIONS:MRI appears to be more sensitive than mammography in detecting tumors in women with an inherited susceptibility to breast cancer.",

keywords = "MUTATION CARRIERS, BRCA2 MUTATION, HIGH-RISK, HISTORY, TRIALS, SURVEILLANCE, OOPHORECTOMY, MASTECTOMY, MORTALITY, DENSITY",

author = "M Kriege and CTM Brekelmans and C Boetes and PE Besnard and HM Zonderland and IM Obdeijn and RA Manoliu and T Kok and H Peterse and MMA Tilanus-Linthorst and SH Muller and S Meijer and JC Oosterwijk and LVAM Beex and RAEM Tollenaar and {de Koning}, HJ and EJT Rutgers and JGM Klijn and {Magnetic Resonance Imaging Screeni}",

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Kriege, M, Brekelmans, CTM, Boetes, C, Besnard, PE, Zonderland, HM, Obdeijn, IM, Manoliu, RA, Kok, T, Peterse, H, Tilanus-Linthorst, MMA, Muller, SH, Meijer, S, Oosterwijk, JC, Beex, LVAM, Tollenaar, RAEM, de Koning, HJ, Rutgers, EJT, Klijn, JGM & Magnetic Resonance Imaging Screeni 2004, 'Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition', New England Journal of Medicine, vol. 351, nr. 5, blz. 427-437.

TY - JOUR

T1 - Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition

AU - Kriege, M

AU - Brekelmans, CTM

AU - Boetes, C

AU - Besnard, PE

AU - Zonderland, HM

AU - Obdeijn, IM

AU - Manoliu, RA

AU - Kok, T

AU - Peterse, H

AU - Tilanus-Linthorst, MMA

AU - Muller, SH

AU - Meijer, S

AU - Oosterwijk, JC

AU - Beex, LVAM

AU - Tollenaar, RAEM

AU - de Koning, HJ

AU - Rutgers, EJT

AU - Klijn, JGM

AU - Magnetic Resonance Imaging Screeni

PY - 2004/7/29

Y1 - 2004/7/29

N2 - BACKGROUND:The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to breast cancer is currently unproven. We compared the efficacy of magnetic resonance imaging (MRI) with that of mammography for screening in this group of high-risk women.METHODS:Women who had a cumulative lifetime risk of breast cancer of 15 percent or more were screened every six months with a clinical breast examination and once a year by mammography and MRI, with independent readings. The characteristics of the cancers that were detected were compared with the characteristics of those in two different age-matched control groups.RESULTS:We screened 1909 eligible women, including 358 carriers of germ-line mutations. Within a median follow-up period of 2.9 years, 51 tumors (44 invasive cancers, 6 ductal carcinomas in situ, and 1 lymphoma) and 1 lobular carcinoma in situ were detected. The sensitivity of clinical breast examination, mammography, and MRI for detecting invasive breast cancer was 17.9 percent, 33.3 percent, and 79.5 percent, respectively, and the specificity was 98.1 percent, 95.0 percent, and 89.8 percent, respectively. The overall discriminating capacity of MRI was significantly better than that of mammography (PCONCLUSIONS:MRI appears to be more sensitive than mammography in detecting tumors in women with an inherited susceptibility to breast cancer.

AB - BACKGROUND:The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to breast cancer is currently unproven. We compared the efficacy of magnetic resonance imaging (MRI) with that of mammography for screening in this group of high-risk women.METHODS:Women who had a cumulative lifetime risk of breast cancer of 15 percent or more were screened every six months with a clinical breast examination and once a year by mammography and MRI, with independent readings. The characteristics of the cancers that were detected were compared with the characteristics of those in two different age-matched control groups.RESULTS:We screened 1909 eligible women, including 358 carriers of germ-line mutations. Within a median follow-up period of 2.9 years, 51 tumors (44 invasive cancers, 6 ductal carcinomas in situ, and 1 lymphoma) and 1 lobular carcinoma in situ were detected. The sensitivity of clinical breast examination, mammography, and MRI for detecting invasive breast cancer was 17.9 percent, 33.3 percent, and 79.5 percent, respectively, and the specificity was 98.1 percent, 95.0 percent, and 89.8 percent, respectively. The overall discriminating capacity of MRI was significantly better than that of mammography (PCONCLUSIONS:MRI appears to be more sensitive than mammography in detecting tumors in women with an inherited susceptibility to breast cancer.

KW - MUTATION CARRIERS

KW - BRCA2 MUTATION

KW - HIGH-RISK

KW - HISTORY

KW - TRIALS

KW - SURVEILLANCE

KW - OOPHORECTOMY

KW - MASTECTOMY

KW - MORTALITY

KW - DENSITY

M3 - Article

SN - 0028-4793

VL - 351

SP - 427

EP - 437

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 5

ER -