TY - JOUR
T1 - Elimination diets' efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder
AU - Ly, Verena
AU - Bottelier, Marco
AU - Hoekstra, Pieter J.
AU - Vasquez, Alejandro Arias
AU - Buitelaar, Jan K.
AU - Rommelse, Nanda N.
PY - 2017/9
Y1 - 2017/9
N2 - Nutrition plays an important role in neurodevelopment. This insight has led to increasing research into the efficacy of nutrition-related interventions for treating neurodevelopmental disorders. This review discusses an elimination diet as a treatment for attention deficit hyperactivity disorder and autism spectrum disorder, with a focus on the efficacy of the food additives exclusion diet, gluten-free/casein-free diet and oligoantigenic diet. Furthermore, we discuss the potential mechanisms of elimination diets' effects in these neurodevelopmental disorders. The main candidate mechanism is the microbiome-gut-brain axis possibly involving complex interactions between multiple systems, including the metabolic, immune, endocrine, and neural system. We conclude with practical implications and future directions into the investigation of an elimination diet's efficacy in the treatment of attention deficit hyperactivity disorder and autism spectrum disorder.
AB - Nutrition plays an important role in neurodevelopment. This insight has led to increasing research into the efficacy of nutrition-related interventions for treating neurodevelopmental disorders. This review discusses an elimination diet as a treatment for attention deficit hyperactivity disorder and autism spectrum disorder, with a focus on the efficacy of the food additives exclusion diet, gluten-free/casein-free diet and oligoantigenic diet. Furthermore, we discuss the potential mechanisms of elimination diets' effects in these neurodevelopmental disorders. The main candidate mechanism is the microbiome-gut-brain axis possibly involving complex interactions between multiple systems, including the metabolic, immune, endocrine, and neural system. We conclude with practical implications and future directions into the investigation of an elimination diet's efficacy in the treatment of attention deficit hyperactivity disorder and autism spectrum disorder.
KW - Elimination diet
KW - Attention deficit/hyperactivity disorder
KW - Autism spectrum disorder
KW - Food sensitivity
KW - Gut-brain interaction
KW - CHAIN FATTY-ACIDS
KW - CASEIN-FREE DIET
KW - FREE/CASEIN-FREE DIET
KW - GUT MICROBIOTA
KW - DEFICIT/HYPERACTIVITY DISORDER
KW - GLUTEN-FREE
KW - NEURODEVELOPMENTAL DISORDERS
KW - GASTROINTESTINAL SYMPTOMS
KW - BRAIN-DEVELOPMENT
KW - FOOD-ADDITIVES
U2 - 10.1007/s00787-017-0959-1
DO - 10.1007/s00787-017-0959-1
M3 - Review article
SN - 1018-8827
VL - 26
SP - 1067
EP - 1079
JO - European Child & Adolescent Psychiatry
JF - European Child & Adolescent Psychiatry
IS - 9
ER -