Emerging regulation and functions of autophagy

Patricia Boya, Patrice Codogno, Fulvio Reggiori

OnderzoeksoutputAcademicpeer review

833 Citaten (Scopus)

Samenvatting

Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.

Originele taal-2English
Pagina's (van-tot)713-20
Aantal pagina's8
TijdschriftNature Cell Biology
Volume15
Nummer van het tijdschrift7
DOI's
StatusPublished - jul-2013
Extern gepubliceerdJa

Citeer dit