Emerging regulation and functions of autophagy

Patricia Boya, Patrice Codogno, Fulvio Reggiori

OnderzoeksoutputAcademicpeer review

833 Citaten (Scopus)


Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.

Originele taal-2English
Pagina's (van-tot)713-20
Aantal pagina's8
TijdschriftNature Cell Biology
Nummer van het tijdschrift7
StatusPublished - jul-2013
Extern gepubliceerdJa

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