Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control Participants

Anders L. Thorsen; Stella J. de Wit; Froukje E. de Vries; Danielle C. Cath; Dick J. Veltman; Ysbrand D. van der Werf; David Mataix-Cols; Bjarne Hansen; Gerd Kvale; Odile A. van den Heuvel

doi:10.1016/j.bpsc.2018.03.007

Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control Participants

Anders L. Thorsen^*, Stella J. de Wit, Froukje E. de Vries, Danielle C. Cath, Dick J. Veltman, Ysbrand D. van der Werf, David Mataix-Cols, Bjarne Hansen, Gerd Kvale, Odile A. van den Heuvel

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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BACKGROUND: Functional neuroimaging endophenotypes of obsessive-compulsive disorder (OCD) have been suggested during executive tasks. The purpose of this study was to investigate whether behavioral and neural responses during emotion processing and regulation also represent an endophenotype of OCD.

METHODS: Forty-three unmedicated adult OCD patients, 19 of their unaffected siblings, and 38 healthy control participants underwent 3T functional magnetic resonance imaging during an emotion regulation task including neutral, fear-inducing, and OCD-related visual stimuli. Stimuli were processed during natural appraisal and during cognitive reappraisal, and distress ratings were collected after each picture. We performed between-group comparisons on task behavior and brain activation in regions of interest during emotion provocation and regulation.

RESULTS: Siblings reported similar distress as healthy control participants during provocation, and significantly less than patients. There was no significant three-group difference in activation during fear provocation or regulation. Three-group comparisons showed that patients had higher amygdala and dorsomedial prefrontal cortex activation during OCD-related emotion provocation and regulation, respectively, while siblings were intermediate between patients and control participants but not significantly different from either. Siblings showed higher left temporooccipital activation (compared with both healthy control participants and patients) and higher frontolimbic connectivity (compared with patients) during OCD-related regulation.

CONCLUSIONS: Unaffected siblings do not show the same distress and amygdala activation during emotional provocation as OCD patients. Siblings show distinct activation in a temporo-occipital region, possibly related to compensatory cognitive control. This suggests that emotion regulation is not a strong endophenotype for OCD. When replicated, this contributes to our understanding of familial risk and resilience for OCD.

Originele taal-2	English
Pagina's (van-tot)	352-360
Aantal pagina's	9
Tijdschrift	Biological psychiatry. Cognitive neuroscience and neuroimaging
Volume	4
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/j.bpsc.2018.03.007
Status	Published - apr.-2019

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Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control ParticipantsFinal publisher's version, 457 KBLicentie: Taverne

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Thorsen, A. L., de Wit, S. J., de Vries, F. E., Cath, D. C., Veltman, D. J., van der Werf, Y. D., Mataix-Cols, D., Hansen, B., Kvale, G., & van den Heuvel, O. A. (2019). Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control Participants. Biological psychiatry. Cognitive neuroscience and neuroimaging, 4(4), 352-360. https://doi.org/10.1016/j.bpsc.2018.03.007

@article{462be881f6514f6b8606c57df454e418,

title = "Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control Participants",

abstract = "BACKGROUND: Functional neuroimaging endophenotypes of obsessive-compulsive disorder (OCD) have been suggested during executive tasks. The purpose of this study was to investigate whether behavioral and neural responses during emotion processing and regulation also represent an endophenotype of OCD.METHODS: Forty-three unmedicated adult OCD patients, 19 of their unaffected siblings, and 38 healthy control participants underwent 3T functional magnetic resonance imaging during an emotion regulation task including neutral, fear-inducing, and OCD-related visual stimuli. Stimuli were processed during natural appraisal and during cognitive reappraisal, and distress ratings were collected after each picture. We performed between-group comparisons on task behavior and brain activation in regions of interest during emotion provocation and regulation.RESULTS: Siblings reported similar distress as healthy control participants during provocation, and significantly less than patients. There was no significant three-group difference in activation during fear provocation or regulation. Three-group comparisons showed that patients had higher amygdala and dorsomedial prefrontal cortex activation during OCD-related emotion provocation and regulation, respectively, while siblings were intermediate between patients and control participants but not significantly different from either. Siblings showed higher left temporooccipital activation (compared with both healthy control participants and patients) and higher frontolimbic connectivity (compared with patients) during OCD-related regulation.CONCLUSIONS: Unaffected siblings do not show the same distress and amygdala activation during emotional provocation as OCD patients. Siblings show distinct activation in a temporo-occipital region, possibly related to compensatory cognitive control. This suggests that emotion regulation is not a strong endophenotype for OCD. When replicated, this contributes to our understanding of familial risk and resilience for OCD.",

keywords = "Emotion regulation, Emotional provocation, Endophenotype, Familial risk, fMRI, Obsessive-compulsive disorder, ENDOPHENOTYPES, METAANALYSIS, INHIBITION, AMYGDALA, SCALE, FEAR",

author = "Thorsen, {Anders L.} and {de Wit}, {Stella J.} and {de Vries}, {Froukje E.} and Cath, {Danielle C.} and Veltman, {Dick J.} and {van der Werf}, {Ysbrand D.} and David Mataix-Cols and Bjarne Hansen and Gerd Kvale and {van den Heuvel}, {Odile A.}",

year = "2019",

month = apr,

doi = "10.1016/j.bpsc.2018.03.007",

language = "English",

volume = "4",

pages = "352--360",

journal = "Biological psychiatry. Cognitive neuroscience and neuroimaging",

issn = "2451-9022",

publisher = "Elsevier",

number = "4",

}

Thorsen, AL, de Wit, SJ, de Vries, FE, Cath, DC, Veltman, DJ, van der Werf, YD, Mataix-Cols, D, Hansen, B, Kvale, G & van den Heuvel, OA 2019, 'Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control Participants', Biological psychiatry. Cognitive neuroscience and neuroimaging, vol. 4, nr. 4, blz. 352-360. https://doi.org/10.1016/j.bpsc.2018.03.007

TY - JOUR

T1 - Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control Participants

AU - Thorsen, Anders L.

AU - de Wit, Stella J.

AU - de Vries, Froukje E.

AU - Cath, Danielle C.

AU - Veltman, Dick J.

AU - van der Werf, Ysbrand D.

AU - Mataix-Cols, David

AU - Hansen, Bjarne

AU - Kvale, Gerd

AU - van den Heuvel, Odile A.

PY - 2019/4

Y1 - 2019/4

N2 - BACKGROUND: Functional neuroimaging endophenotypes of obsessive-compulsive disorder (OCD) have been suggested during executive tasks. The purpose of this study was to investigate whether behavioral and neural responses during emotion processing and regulation also represent an endophenotype of OCD.METHODS: Forty-three unmedicated adult OCD patients, 19 of their unaffected siblings, and 38 healthy control participants underwent 3T functional magnetic resonance imaging during an emotion regulation task including neutral, fear-inducing, and OCD-related visual stimuli. Stimuli were processed during natural appraisal and during cognitive reappraisal, and distress ratings were collected after each picture. We performed between-group comparisons on task behavior and brain activation in regions of interest during emotion provocation and regulation.RESULTS: Siblings reported similar distress as healthy control participants during provocation, and significantly less than patients. There was no significant three-group difference in activation during fear provocation or regulation. Three-group comparisons showed that patients had higher amygdala and dorsomedial prefrontal cortex activation during OCD-related emotion provocation and regulation, respectively, while siblings were intermediate between patients and control participants but not significantly different from either. Siblings showed higher left temporooccipital activation (compared with both healthy control participants and patients) and higher frontolimbic connectivity (compared with patients) during OCD-related regulation.CONCLUSIONS: Unaffected siblings do not show the same distress and amygdala activation during emotional provocation as OCD patients. Siblings show distinct activation in a temporo-occipital region, possibly related to compensatory cognitive control. This suggests that emotion regulation is not a strong endophenotype for OCD. When replicated, this contributes to our understanding of familial risk and resilience for OCD.

AB - BACKGROUND: Functional neuroimaging endophenotypes of obsessive-compulsive disorder (OCD) have been suggested during executive tasks. The purpose of this study was to investigate whether behavioral and neural responses during emotion processing and regulation also represent an endophenotype of OCD.METHODS: Forty-three unmedicated adult OCD patients, 19 of their unaffected siblings, and 38 healthy control participants underwent 3T functional magnetic resonance imaging during an emotion regulation task including neutral, fear-inducing, and OCD-related visual stimuli. Stimuli were processed during natural appraisal and during cognitive reappraisal, and distress ratings were collected after each picture. We performed between-group comparisons on task behavior and brain activation in regions of interest during emotion provocation and regulation.RESULTS: Siblings reported similar distress as healthy control participants during provocation, and significantly less than patients. There was no significant three-group difference in activation during fear provocation or regulation. Three-group comparisons showed that patients had higher amygdala and dorsomedial prefrontal cortex activation during OCD-related emotion provocation and regulation, respectively, while siblings were intermediate between patients and control participants but not significantly different from either. Siblings showed higher left temporooccipital activation (compared with both healthy control participants and patients) and higher frontolimbic connectivity (compared with patients) during OCD-related regulation.CONCLUSIONS: Unaffected siblings do not show the same distress and amygdala activation during emotional provocation as OCD patients. Siblings show distinct activation in a temporo-occipital region, possibly related to compensatory cognitive control. This suggests that emotion regulation is not a strong endophenotype for OCD. When replicated, this contributes to our understanding of familial risk and resilience for OCD.

KW - Emotion regulation

KW - Emotional provocation

KW - Endophenotype

KW - Familial risk

KW - fMRI

KW - Obsessive-compulsive disorder

KW - ENDOPHENOTYPES

KW - METAANALYSIS

KW - INHIBITION

KW - AMYGDALA

KW - SCALE

KW - FEAR

U2 - 10.1016/j.bpsc.2018.03.007

DO - 10.1016/j.bpsc.2018.03.007

M3 - Article

SN - 2451-9022

VL - 4

SP - 352

EP - 360

JO - Biological psychiatry. Cognitive neuroscience and neuroimaging

JF - Biological psychiatry. Cognitive neuroscience and neuroimaging

IS - 4

ER -

Emotion Regulation in Obsessive-Compulsive Disorder, Unaffected Siblings, and Unrelated Healthy Control Participants

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