Epigenetic differences between sister chromatids?

Peter M. Lansdorp*, Ester Falconer, Jiang Tao, Julie Brind'Amour, Ulrike Naumann

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

16 Citaten (Scopus)


Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear. Many chromatin marks are likely to be copied onto both sister chromatids in conjunction with DNA replication, whereas others could be distributed randomly between sister chromatids. Epigenetic differences between sister chromatids could also emerge in a more predictable manner, for example, following processes that are associated with lagging strand DNA replication. The resulting epigenetic differences between sister chromatids could result in different gene expression patterns in daughter cells. This possibility has been difficult to test because techniques to distinguish between parental sister chromatids require analysis of single cells and are not obvious. Here, we briefly review the topic of sister chromatid epigenetics and discuss how the identification of sister chromatids in cells could change the way we think about asymmetric cell divisions and stochastic variation in gene expression between cells in general and paired daughter cells in particular.

Originele taal-2English
RedacteurenL Kanz, WE Fibbe, C Lengerke, JE Dick
Plaats van productieOXFORD
UitgeverijBlackwell Publishing
Aantal pagina's6
ISBN van geprinte versie978-1-57331-867-9
StatusPublished - 2012
Evenement8th International Conference and Workshop on Hematopoietic Stem Cells - , Germany
Duur: 22-sep-201124-sep-2011

Publicatie series

NaamAnnals of the New York Academy of Sciences
ISSN van geprinte versie0077-8923


Other8th International Conference and Workshop on Hematopoietic Stem Cells

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