Epigenetic perturbations in aging stem cells

Sara Russo Krauss, Gerald de Haan*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articleAcademicpeer review

6 Citaten (Scopus)
426 Downloads (Pure)

Samenvatting

Stem cells maintain homeostasis in all regenerating tissues during the lifespan of an organism. Thus, age-related functional decline of such tissues is likely to be at least partially explained by molecular events occurring in the stem cell compartment. Some of these events involve epigenetic changes, which may dictate how an aging genome can lead to differential gene expression programs. Recent technological advances have made it now possible to assess the genome-wide distribution of an ever-increasing number of epigenetic marks. As a result, the hypothesis that there may be a causal role for an altered epigenome contributing to the functional decline of cells, tissues, and organs in aging organisms can now be explored. In this paper, we review recent developments in the field of epigenetic regulation of stem cells, and how this may contribute to aging.

Originele taal-2English
Pagina's (van-tot)396-406
Aantal pagina's11
TijdschriftMammalian Genome
Volume27
Nummer van het tijdschrift7-8
DOI's
StatusPublished - aug-2016

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