Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

Angelina Osipyan; Deng Chen; Frank J. Dekker

doi:10.1016/j.drudis.2021.03.012

Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

Angelina Osipyan, Deng Chen, Frank J. Dekker^*

^*Corresponding author voor dit werk

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30 Citaten (Scopus)

222 Downloads (Pure)

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Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.

Originele taal-2	English
Pagina's (van-tot)	1728-1734
Tijdschrift	Drug Discovery Today
Volume	26
Nummer van het tijdschrift	7
Vroegere onlinedatum	18-mrt.-2021
DOI's	https://doi.org/10.1016/j.drudis.2021.03.012
Status	Published - jul.-2021

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10.1016/j.drudis.2021.03.012Licentie: CC BY

Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammationFinal publisher's version, 1,11 MBLicentie: CC BY

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title = "Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation",

abstract = "Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.",

author = "Angelina Osipyan and Deng Chen and Dekker, {Frank J.}",

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AU - Osipyan, Angelina

AU - Chen, Deng

AU - Dekker, Frank J.

PY - 2021/7

Y1 - 2021/7

N2 - Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.

AB - Epigenetic mechanisms are important for the regular development and maintenance of the tissue-specific expression of cytokine genes. One of the crucial cytokines involved in cancer and inflammation is macrophage migration inhibitory factor (MIF), which triggers the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling pathways by binding to CD74 and other receptors. Altered expression of this cytokine and altered activity states of the connected pathways are linked to inflammatory disease and cancer. Therapeutic strategies based on epigenetic mechanisms have the potential to regulate MIF-mediated signaling in cancer and inflammation.

U2 - 10.1016/j.drudis.2021.03.012

DO - 10.1016/j.drudis.2021.03.012

M3 - Review article

C2 - 33746067

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SP - 1728

EP - 1734

JO - Drug Discovery Today

JF - Drug Discovery Today

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Epigenetic regulation in macrophage migration inhibitory factor (MIF)-mediated signaling in cancer and inflammation

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