Epithelial cell-cell junctions and plasma membrane domains

Ben N. G. Giepmans, Sven C. D. van Ijzendoorn*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

124 Citaten (Scopus)


Epithelial cells form a barrier against the environment, but are also required for the regulated exchange of molecules between an organism and its surroundings. Epithelial cells are characterised by a remarkable polarization of their plasma membrane, evidenced by the appearance of structurally, compositionally, and functionally distinct surface domains. Here we consider the (in)dependence of epithelial cell polarisation and the function of smaller plasma membrane domains (e.g. adherens junctions, gap junctions, tight junctions, apical lipid rafts, caveolae, and clathrin-coated pits) in the development and maintenance of cell surface polarity. Recent evidence of cross-talk and/or overlap between the different cell-cell junction components and alternate functions of junction components, including gene expression regulation, are discussed in the context of cell surface polarity. (C) 2008 Elsevier B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)820-831
Aantal pagina's12
TijdschriftBiochimica et Biophysica Acta-Biomembranes
Nummer van het tijdschrift4
StatusPublished - apr.-2009

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