Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival

Hendrik Folkerts, Carin L. E. Hazenberg, Ewout J. Houwerzijl, Fiona A. J. van den Heuvel, Andre B. Mulder, Johannes J. L. van der Want, Edo Vellenga*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

3 Citaten (Scopus)


To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fraction with those from the hematon fraction, which are compacted complexes of hematopoietic cells surrounded by their own micro-environment. In directly fixed materials, erythroblasts exhibited signs of autophagy with limited apoptosis (

Originele taal-2English
Pagina's (van-tot)215-222.e2
Aantal pagina's10
TijdschriftExperimental Hematology
Nummer van het tijdschrift3
StatusPublished - mrt.-2015

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