Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival

Hendrik Folkerts; Carin L. E. Hazenberg; Ewout J. Houwerzijl; Fiona A. J. van den Heuvel; Andre B. Mulder; Johannes J. L. van der Want; Edo Vellenga

doi:10.1016/j.exphem.2014.11.005

Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival

Hendrik Folkerts, Carin L. E. Hazenberg, Ewout J. Houwerzijl, Fiona A. J. van den Heuvel, Andre B. Mulder, Johannes J. L. van der Want, Edo Vellenga^*

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

3 Citaten (Scopus)

Samenvatting

To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fraction with those from the hematon fraction, which are compacted complexes of hematopoietic cells surrounded by their own micro-environment. In directly fixed materials, erythroblasts exhibited signs of autophagy with limited apoptosis (

Originele taal-2	English
Pagina's (van-tot)	215-222.e2
Aantal pagina's	10
Tijdschrift	Experimental Hematology
Volume	43
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/j.exphem.2014.11.005
Status	Published - mrt.-2015

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Erythroid progenitors from patients with low-risk myelodysplastic syndromes
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Folkerts, H., Hazenberg, C. L. E., Houwerzijl, E. J., van den Heuvel, F. A. J., Mulder, A. B., van der Want, J. J. L., & Vellenga, E. (2015). Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival. Experimental Hematology, 43(3), 215-222.e2. https://doi.org/10.1016/j.exphem.2014.11.005

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abstract = "To investigate whether the type of programmed cell death of myelodysplastic erythroid cells depends on their cellular context, we performed studies on cells from patients with low-risk myelodysplastic syndromes. We compared erythroid cells (and their precursor cells) from the mononuclear cell fraction with those from the hematon fraction, which are compacted complexes of hematopoietic cells surrounded by their own micro-environment. In directly fixed materials, erythroblasts exhibited signs of autophagy with limited apoptosis (",

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AU - Folkerts, Hendrik

AU - Hazenberg, Carin L. E.

AU - Houwerzijl, Ewout J.

AU - van den Heuvel, Fiona A. J.

AU - Mulder, Andre B.

AU - van der Want, Johannes J. L.

AU - Vellenga, Edo

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KW - ACUTE MYELOID-LEUKEMIA

KW - BONE-MARROW

KW - ENHANCED AUTOPHAGY

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KW - MEGAKARYOCYTES

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