Estrogen regulates aquaporin-2 expression in the kidney

Stine Julie Tingskov, Henricus A.M. Mutsaers, Rikke Nørregaard*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

1 Citaat (Scopus)

Samenvatting

Estrogens are primarily identified as sex hormones that, for a long time, have been known as important regulators of female reproductive physiology. However, our understanding of the role of estrogens has changed over the past years. It is now well accepted that estrogens are also involved in other physiological and pathological processes in both genders. This is due to the fact that estrogen can act both local as well as on a systemic level. Next to its role in reproductive physiology, there is accumulating evidence that estrogen influences multiple systems involved in water homeostasis. This chapter will delineate the regulatory effects of estrogen on the water channel aquaporin-2 (AQP2) found in the renal collecting duct. We will first provide an introduction to estrogen, the estrogen receptors and their role in renal physiology as well as describe the effect of selective estrogen receptor modulators (SERMs) on the kidney. Subsequently, we will focus on how estrogen and SERMs influence water balance and regulate AQP2 expression in principal cells of the collecting duct. Finally, we will describe how estrogen regulates AQP2 functionality in other organ systems.

Originele taal-2English
TitelVitamins and Hormones
RedacteurenGerald Litwack
UitgeverijACADEMIC PRESS INC ELSEVIER SCIENCE
Hoofdstuk11
Pagina's243-264
Aantal pagina's22
ISBN van geprinte versie9780128208090
DOI's
StatusPublished - 2020
Extern gepubliceerdJa

Publicatie series

NaamVitamins and Hormones
Volume112
ISSN van geprinte versie0083-6729

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