European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part IV: deep brain stimulation

Natalia Szejko*, Yulia Worbe, Andreas Hartmann, Veerle Visser-Vandewalle, Linda Ackermans, Christos Ganos, Mauro Porta, Albert F.G. Leentjens, Jan Hinnerk Mehrkens, Daniel Huys, Juan Carlos Baldermann, Jens Kuhn, Carine Karachi, Cécile Delorme, Thomas Foltynie, Andrea E. Cavanna, Danielle Cath, Kirsten Müller-Vahl

*Bijbehorende auteur voor dit werk

    Onderzoeksoutputpeer review

    24 Citaten (Scopus)
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    In 2011 the European Society for the Study of Tourette Syndrome (ESSTS) published its first European clinical guidelines for the treatment of Tourette Syndrome (TS) with part IV on deep brain stimulation (DBS). Here, we present a revised version of these guidelines with updated recommendations based on the current literature covering the last decade as well as a survey among ESSTS experts. Currently, data from the International Tourette DBS Registry and Database, two meta-analyses, and eight randomized controlled trials (RCTs) are available. Interpretation of outcomes is limited by small sample sizes and short follow-up periods. Compared to open uncontrolled case studies, RCTs report less favorable outcomes with conflicting results. This could be related to several different aspects including methodological issues, but also substantial placebo effects. These guidelines, therefore, not only present currently available data from open and controlled studies, but also include expert knowledge. Although the overall database has increased in size since 2011, definite conclusions regarding the efficacy and tolerability of DBS in TS are still open to debate. Therefore, we continue to consider DBS for TS as an experimental treatment that should be used only in carefully selected, severely affected and otherwise treatment-resistant patients.

    Originele taal-2English
    Pagina's (van-tot)443–461
    Aantal pagina's19
    TijdschriftEuropean Child and Adolescent Psychiatry
    Nummer van het tijdschrift3
    Vroegere onlinedatum4-okt.-2021
    StatusPublished - 1-mrt.-2022

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