TY - JOUR
T1 - European Society for Organ Transplantation (ESOT) Consensus Statement on the Role of Pancreas Machine Perfusion to Increase the Donor Pool for Beta Cell Replacement Therapy
AU - ESOT Guidelines Taskforce
AU - Ferrer-Fàbrega, Joana
AU - Mesnard, Benoît
AU - Messner, Franka
AU - Doppenberg, Jason B.
AU - Drachenberg, Cinthia
AU - Engelse, Marten A.
AU - Johnson, Paul R.V.
AU - Leuvenink, Henri G.D.
AU - Oniscu, Gabriel C.
AU - Papalois, Vassilios
AU - Ploeg, Rutger J.
AU - Reichman, Trevor W.
AU - Scott, William E.
AU - Vistoli, Fabio
AU - Berney, Thierry
AU - Jacobs-Tulleneers-Thevissen, Daniel
AU - Kessaris, Nicos
AU - Weissenbacher, Annemarie
AU - Ogbemudia, Ann Etohan
AU - White, Steve
AU - Branchereau, Julien
N1 - Publisher Copyright:
Copyright © 2023 Ferrer-Fàbrega, Mesnard, Messner, Doppenberg, Drachenberg, Engelse, Johnson, Leuvenink, Oniscu, Papalois, Ploeg, Reichman, Scott, Vistoli, Berney, Jacobs-Tulleneers-Thevissen, Kessaris, Weissenbacher, Ogbemudia, White and Branchereau.
PY - 2023/7/19
Y1 - 2023/7/19
N2 - The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidney’s and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the “Role of pancreas machine perfusion to increase the donor pool for beta cell replacement,” the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague.
AB - The advent of Machine Perfusion (MP) as a superior form of preservation and assessment for cold storage of both high-risk kidney’s and the liver presents opportunities in the field of beta-cell replacement. It is yet unknown whether such techniques, when applied to the pancreas, can increase the pool of suitable donor organs as well as ameliorating the effects of ischemia incurred during the retrieval process. Recent experimental models of pancreatic MP appear promising. Applications of MP to the pancreas, needs refinement regarding perfusion protocols and organ viability assessment criteria. To address the “Role of pancreas machine perfusion to increase the donor pool for beta cell replacement,” the European Society for Organ Transplantation (ESOT) assembled a dedicated working group comprising of experts to review literature pertaining to the role of MP as a method of improving donor pancreas quality as well as quantity available for transplant, and to develop guidelines founded on evidence-based reviews in experimental and clinical settings. These were subsequently refined during the Consensus Conference when this took place in Prague.
KW - ischemia-reperfusion injury
KW - islet transplantation
KW - machine perfusion
KW - persufflation
KW - whole pancreas transplantation
UR - http://www.scopus.com/inward/record.url?scp=85166770608&partnerID=8YFLogxK
U2 - 10.3389/ti.2023.11374
DO - 10.3389/ti.2023.11374
M3 - Article
C2 - 37547751
AN - SCOPUS:85166770608
SN - 0934-0874
VL - 36
JO - Transplant International
JF - Transplant International
M1 - 11374
ER -