Evaluation of six methylation markers derived from genome-wide screens for detection of cervical precancer and cancer

Stèfanie Dick, Lisanne Verhoef, Lise Ma De Strooper, Iuliana Ciocănea-Teodorescu, G Bea A Wisman, Chris Jlm Meijer, Maaike Cg Bleeker, Renske Dm Steenbergen, Daniëlle Am Heideman*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)

Samenvatting

Aim:To evaluate the triage performance of six host-cell DNA methylation markers derived from two genome-wide discovery screens for detection of cervical precancer (cervical intraepithelial neoplasia 3 [CIN]) and cancer.Materials & methods:Human papillomavirus-positive cervical scrapes of controls (0.800 after leave-one-out cross-validation. Bi-marker panelASCL1/LHX8had highest area under the curve (0.882), and detected 83.4% of CIN3 and all cervical cancers at specificity of 82.4%.Conclusion:All six methylation markers showed an equivalent, high performance for the triage of human papillomavirus-positive women using cervical scrapes with complementarity between markers.

Originele taal-2English
Pagina's (van-tot)1569-1578
Aantal pagina's10
TijdschriftEpigenomics
Volume12
Nummer van het tijdschrift18
Vroegere onlinedatum17-sep-2020
DOI's
StatusPublished - sep-2020

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