TY - JOUR
T1 - Evidence-Based Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease
AU - Beldhuis, Iris E.
AU - Lam, Carolyn S. P.
AU - Testani, Jeffrey M.
AU - Voors, Adriaan A.
AU - Van Spall, Harriette G. C.
AU - ter Maaten, Jozine M.
AU - Damman, Kevin
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Chronic kidney disease (CKD) as identified by a reduced estimated glomerular filtration rate (eGFR) is a common comorbidity in patients with heart failure with reduced ejection fraction (HFrEF). The presence of CKD is associated with more severe heart failure, and CKD itself is a strong independent risk factor of poor cardiovascular outcome. Furthermore, the presence of CKD often influences the decision to start, uptitrate, or discontinue possible life-saving HFrEF therapies. Because pivotal HFrEF randomized clinical trials have historically excluded patients with stage 4 and 5 CKD (eGFR
AB - Chronic kidney disease (CKD) as identified by a reduced estimated glomerular filtration rate (eGFR) is a common comorbidity in patients with heart failure with reduced ejection fraction (HFrEF). The presence of CKD is associated with more severe heart failure, and CKD itself is a strong independent risk factor of poor cardiovascular outcome. Furthermore, the presence of CKD often influences the decision to start, uptitrate, or discontinue possible life-saving HFrEF therapies. Because pivotal HFrEF randomized clinical trials have historically excluded patients with stage 4 and 5 CKD (eGFR
KW - chronic kidney disease
KW - evidence-based treatment
KW - heart failure with reduced ejection fraction
KW - WORSENING RENAL-FUNCTION
KW - LEFT-VENTRICULAR DYSFUNCTION
KW - CONVERTING-ENZYME-INHIBITOR
KW - CARDIAC-INSUFFICIENCY BISOPROLOL
KW - RANDOMIZED INTERVENTION TRIAL
KW - MILD PATIENTS HOSPITALIZATION
KW - ACUTE MYOCARDIAL-INFARCTION
KW - II CIBIS-II
KW - CARDIORENAL SYNDROME
KW - ALDOSTERONE BLOCKER
U2 - 10.1161/CIRCULATIONAHA.121.052792
DO - 10.1161/CIRCULATIONAHA.121.052792
M3 - Article
SN - 0009-7322
VL - 145
SP - 693
EP - 712
JO - Circulation
JF - Circulation
IS - 9
ER -