Exchange pathways of plastoquinone and plastoquinol in the photosystem II complex

Floris J. Van Eerden, Manuel N. Melo, Pim W. J. M. Frederix, Xavier Periole, Siewert J. Marrink*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

57 Citaten (Scopus)
320 Downloads (Pure)

Samenvatting

Plastoquinone (PLQ) acts as an electron carrier between photosystem II (PSII) and the cytochrome b(6)f complex. To understand how PLQ enters and leaves PSII, here we show results of coarse grained molecular dynamics simulations of PSII embedded in the thylakoid membrane, covering a total simulation time of more than 0.5 ms. The long time scale allows the observation of many spontaneous entries of PLQ into PSII, and the unbinding of plastoquinol (PLQol) from the complex. In addition to the two known channels, we observe a third channel for PLQ/PLQol diffusion between the thylakoid membrane and the PLQ binding sites. Our simulations point to a promiscuous diffusion mechanism in which all three channels function as entry and exit channels. The exchange cavity serves as a PLQ reservoir. Our simulations provide a direct view on the exchange of electron carriers, a key step of the photosynthesis machinery.

Originele taal-2English
Artikelnummer15214
Pagina's (van-tot)1-8
Aantal pagina's8
TijdschriftNature Communications
Volume8
DOI's
StatusPublished - 10-mei-2017

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