Exploring combined influences of material topography, stiffness and chemistry on cell behavior at biointerfaces

Qihui Zhou

Exploring combined influences of material topography, stiffness and chemistry on cell behavior at biointerfaces

Vertaalde titel van de bijdrage: Verkenning van de gecombineerde invloeden van de topografie, stijfheid en chemie van biomateriaaloppervlakken op het gedrag van cellen

Qihui Zhou

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Complexe materiaalgrensvlakken zijn ontworpen voor het exploreren van cel-materiaal interactions om de relatie tussen biomateriaal eigenschappen en biologische prestatie blood te leggen welke in de toekomst gebruikt kan worden voor geadvanceerde weefselbouw en regeneratieve geneeskunde. Cellen nemen altijd verscheidene signalen op uit hun microomgeving en hierdoor moeten we vele verschillende parameters van de biomaterialen incorporeren zodat we deze gedragingen zo accuraat mogelijk kunnen bestuderen en de toestand van de cel koppelen aan de interactie die wordt aangegaan met de materiaal eigenschappen. Om controle te verkrijgen over cel gedrag en deze te kunnen sturen, is het cruciaal om optimaal celgedrag te bepalen waarbij in detail naar een groot aantal parameterwaardes wordt gekeken binnen een groot spreidingsgebied. Naar verwachting illusteren de bevindingen beschreven in dit proefschrift andere onderzoekers dat celgedrag in een complexere mix van stimuli moet worden bestudeerd. Ons werk zoals hier beschreven gaat niet alleen om het verkrijgen van meer kennis op het gebied van celgedrag omder invloed van materiaaleigenschappen maar ook om het toe te passen als manier om hoogwaardige biomaterialen te ontwikkelen voor commerciele doeleinden.

Vertaalde titel van de bijdrage	Verkenning van de gecombineerde invloeden van de topografie, stijfheid en chemie van biomateriaaloppervlakken op het gedrag van cellen
Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Busscher, Henk, Supervisor van Rijn, Patrick, Co-supervisor
Datum van toekenning	11-jul.-2018
Plaats van publicatie	[Groningen]
Uitgever	Rijksuniversiteit Groningen
Gedrukte ISBN's	978-94-034-0780-7
Elektronische ISBN's	978-94-034-0779-1
Status	Published - 2018

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Title and contentsFinal publisher's version, 360 KB
Chapter 1Final publisher's version, 2,01 MB
Chapter 2Final publisher's version, 19 MB
Chapter 3Final publisher's version, 12,3 MB
Chapter 4Final publisher's version, 13 MB
Chapter 5Final publisher's version, 27 MB
Chapter 6Final publisher's version, 5,35 MB
Chapter 7Final publisher's version, 833 KB
SummaryFinal publisher's version, 116 KB
SamenvattingFinal publisher's version, 118 KB
AcknowledgementsFinal publisher's version, 131 KB
Curriculum Vitae, List of publicationsFinal publisher's version, 126 KB
Complete thesisFinal publisher's version, 79,2 MB
PropositionsFinal publisher's version, 38,2 KB

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title = "Exploring combined influences of material topography, stiffness and chemistry on cell behavior at biointerfaces",

abstract = "Complex material interfaces were designed and developed to explore cell-material interactions and elicit the relationship between biomaterial properties and biological performance to be used in the future as possible advanced tissue engineering and regenerative medicine approaches. Cells always integrate multiple cues from their microenvironment and we should include as many different parameters in our biomaterials as possible and study these for an accurate description of the cell state as a consequence of interacting with a material. In order to highly control cellular behavior, it is crucial to identify the optimal cell response by studying a detailed interaction between cells and materials over a broad range. The findings in this thesis are expected to act as a catalyst for other researchers to efficiently explore cell behavior from a more complex point of view. Our work is not just to obtain more knowledge on cell and material interactions, but to apply this knowledge for accelerating the development of high-performance biomaterials, which can become commercially available.",

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AU - Zhou, Qihui

PY - 2018

Y1 - 2018

N2 - Complex material interfaces were designed and developed to explore cell-material interactions and elicit the relationship between biomaterial properties and biological performance to be used in the future as possible advanced tissue engineering and regenerative medicine approaches. Cells always integrate multiple cues from their microenvironment and we should include as many different parameters in our biomaterials as possible and study these for an accurate description of the cell state as a consequence of interacting with a material. In order to highly control cellular behavior, it is crucial to identify the optimal cell response by studying a detailed interaction between cells and materials over a broad range. The findings in this thesis are expected to act as a catalyst for other researchers to efficiently explore cell behavior from a more complex point of view. Our work is not just to obtain more knowledge on cell and material interactions, but to apply this knowledge for accelerating the development of high-performance biomaterials, which can become commercially available.

AB - Complex material interfaces were designed and developed to explore cell-material interactions and elicit the relationship between biomaterial properties and biological performance to be used in the future as possible advanced tissue engineering and regenerative medicine approaches. Cells always integrate multiple cues from their microenvironment and we should include as many different parameters in our biomaterials as possible and study these for an accurate description of the cell state as a consequence of interacting with a material. In order to highly control cellular behavior, it is crucial to identify the optimal cell response by studying a detailed interaction between cells and materials over a broad range. The findings in this thesis are expected to act as a catalyst for other researchers to efficiently explore cell behavior from a more complex point of view. Our work is not just to obtain more knowledge on cell and material interactions, but to apply this knowledge for accelerating the development of high-performance biomaterials, which can become commercially available.

M3 - Thesis fully internal (DIV)

SN - 978-94-034-0780-7

PB - Rijksuniversiteit Groningen

CY - [Groningen]

ER -

Exploring combined influences of material topography, stiffness and chemistry on cell behavior at biointerfaces

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