Exploring Redox Biology in physiology and disease

Anne Koning

Exploring Redox Biology in physiology and disease

Vertaalde titel van de bijdrage: Een verkenning van Redox Biologie in gezondheid en ziekte

Anne Koning

Onderzoeksoutput

3699 Downloads (Pure)

Samenvatting

Oxidatie-reductie-, of redoxreacties zijn verantwoordelijk voor de regulatie van allerhande processen die zich afspelen in het menselijk lichaam. Onder de meest gunstige omstandigheden zijn oxidatie en reductie in balans en draagt een netwerk van redox-actieve verbindingen zorg voor een snelle verwerking van signalen waardoor het lichaam adequaat kan reageren op zowel interne als omgevingsfactoren. Ook de beruchte zuurstof, stikstof en sulfur radicalen vervullen dan waardevolle signaalfuncties. Pas wanneer de balans tussen oxidatie en reductie verstoord raakt, veroorzaken deze de oxidatieve stress die een rol speelt bij het ontstaan van ziekte. Voor dit proefschrift werden verschillende elementen van het redoxnetwerk, waaronder thiolen en (metabolieten van) gasvormige signaalmoleculen waterstofsulfide (H2S) en stikstofoxide (NO), bestudeerd in mens en dier. Thiolen zijn functionele groepen bestaande uit een sulfur en een waterstof atoom en nemen een centrale plaats in bij de overdracht van signalen. H2S en NO kunnen in reactie met thiolen zowel bescherming bieden tegen schade door verregaande oxidatie, als regulerende functies uitoefenen. Zoals in dit proefschrift wordt aangetoond, is de beschikbare hoeveelheid niet geoxideerde thiolen verlaagd in het geval van ziekte. De mate waarin dit het geval is, vertoont een duidelijke samenhang met het ziektebeloop. Datzelfde geldt voor de verwerking van H2S en NO metabolieten, sulfaat en nitraat, door de nier. Dit proefschrift is dan ook een pleidooi voor erkenning van de belangrijke rol van redoxreacties in gezondheid en ziekte en roept op tot verder onderzoek om therapeutisch ingrijpen in het redox systeem in de toekomst mogelijk te maken.

Vertaalde titel van de bijdrage	Een verkenning van Redox Biologie in gezondheid en ziekte
Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Begeleider(s)/adviseur	van Goor, Harry, Supervisor Leuvenink, Henri, Supervisor Feelisch, Martin, Supervisor, Externe Persoon Gaillard, Carlo Ajm, Beoordelingscommissie, Externe Persoon
Datum van toekenning	19-jun.-2017
Plaats van publicatie	[Groningen]
Uitgever	Rijksuniversiteit Groningen
Gedrukte ISBN's	978-94-6233-625-4
Elektronische ISBN's	978-94-6233-637-7
Status	Published - 2017

Toegang tot document

Title and contentsFinal publisher's version, 459 KB
Chapter 1Final publisher's version, 693 KB
Chapter 2Final publisher's version, 2,46 MB
Chapter 3Final publisher's version, 2,27 MB
Chapter 4Final publisher's version, 1,22 MB
Chapter 5Final publisher's version, 1,96 MB
Chapter 6Final publisher's version, 794 KB
Chapter 7Final publisher's version, 1,06 MB
Chapter 8Final publisher's version, 4,27 MB
Chapter 9Final publisher's version, 1,57 MB
Chapter 10Final publisher's version, 1,02 MB
Chapter 11Final publisher's version, 2,06 MB
Chapter 12Final publisher's version, 695 KB
AppendicesFinal publisher's version, 532 KB
Complete thesisFinal publisher's version, 14,2 MB
PropositionsFinal publisher's version, 624 KB

Handle.net

Permanente koppeling

Citeer dit

@phdthesis{670808be472d4434bf92de1d5c135eb1,

title = "Exploring Redox Biology in physiology and disease",

abstract = "Oxidation-reduction or redox reactions are responsible for the regulation of numerous bodily processes. Under the most favourable conditions oxidation and reduction are in balance and a network of redox-active compounds provides the rapid sensing and signalling that allows the body to adequately adapt to internal as well as environmental changes. In these circumstances even the notorious reactive oxygen, nitrogen and sulfur species are involved in physiological processes. Indeed, only when the balance between oxidation and reduction is disturbed do these cause the oxidative stress that is related to disease development. For this thesis several elements of the redox network, including thiols and (metabolites of) gaseous signalling molecules, hydrogen sulfide (H2S) and nitric oxide (NO), were studied in experimental animals and in humans. Thiols are functional groups consisting of a sulfur and a hydrogen atom and are central to the relaying of signals. In reaction with thiols, H2S and NO can protect against damage caused by excessive oxidation and can exert regulatory functions. As is shown in this thesis, the amount of available, unoxidized thiols is reduced in disease. The extent to which this is the case is strongly related to the disease course. The same applies to the regulation of H2S and NO metabolites, sulfate and nitrate, by the kidney. Therefore, this thesis is a plea for acknowledgement of the significance of redox signalling in physiology and disease and calls for further research to allow this concept to be exploited therapeutically in the future.",

author = "Anne Koning",

year = "2017",

language = "English",

isbn = "978-94-6233-625-4",

publisher = "Rijksuniversiteit Groningen",

}

TY - BOOK

T1 - Exploring Redox Biology in physiology and disease

AU - Koning, Anne

PY - 2017

Y1 - 2017

N2 - Oxidation-reduction or redox reactions are responsible for the regulation of numerous bodily processes. Under the most favourable conditions oxidation and reduction are in balance and a network of redox-active compounds provides the rapid sensing and signalling that allows the body to adequately adapt to internal as well as environmental changes. In these circumstances even the notorious reactive oxygen, nitrogen and sulfur species are involved in physiological processes. Indeed, only when the balance between oxidation and reduction is disturbed do these cause the oxidative stress that is related to disease development. For this thesis several elements of the redox network, including thiols and (metabolites of) gaseous signalling molecules, hydrogen sulfide (H2S) and nitric oxide (NO), were studied in experimental animals and in humans. Thiols are functional groups consisting of a sulfur and a hydrogen atom and are central to the relaying of signals. In reaction with thiols, H2S and NO can protect against damage caused by excessive oxidation and can exert regulatory functions. As is shown in this thesis, the amount of available, unoxidized thiols is reduced in disease. The extent to which this is the case is strongly related to the disease course. The same applies to the regulation of H2S and NO metabolites, sulfate and nitrate, by the kidney. Therefore, this thesis is a plea for acknowledgement of the significance of redox signalling in physiology and disease and calls for further research to allow this concept to be exploited therapeutically in the future.

AB - Oxidation-reduction or redox reactions are responsible for the regulation of numerous bodily processes. Under the most favourable conditions oxidation and reduction are in balance and a network of redox-active compounds provides the rapid sensing and signalling that allows the body to adequately adapt to internal as well as environmental changes. In these circumstances even the notorious reactive oxygen, nitrogen and sulfur species are involved in physiological processes. Indeed, only when the balance between oxidation and reduction is disturbed do these cause the oxidative stress that is related to disease development. For this thesis several elements of the redox network, including thiols and (metabolites of) gaseous signalling molecules, hydrogen sulfide (H2S) and nitric oxide (NO), were studied in experimental animals and in humans. Thiols are functional groups consisting of a sulfur and a hydrogen atom and are central to the relaying of signals. In reaction with thiols, H2S and NO can protect against damage caused by excessive oxidation and can exert regulatory functions. As is shown in this thesis, the amount of available, unoxidized thiols is reduced in disease. The extent to which this is the case is strongly related to the disease course. The same applies to the regulation of H2S and NO metabolites, sulfate and nitrate, by the kidney. Therefore, this thesis is a plea for acknowledgement of the significance of redox signalling in physiology and disease and calls for further research to allow this concept to be exploited therapeutically in the future.

M3 - Thesis fully internal (DIV)

SN - 978-94-6233-625-4

PB - Rijksuniversiteit Groningen

CY - [Groningen]

ER -

Exploring Redox Biology in physiology and disease

Samenvatting

Toegang tot document

Handle.net

Vingerafdruk

Citeer dit