Export and modification of (poly)peptides in the lantibiotic way

Gert Nikolaas Moll (Uitvinder), Cornelis Johannes Leenhouts (Uitvinder), Oscar Paul Kuipers (Uitvinder), Arnold Jacob Mathieu Driessen (Uitvinder)

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The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine-containing peptides, wherein extracellularly thioether rings may be formed.
Originele taal-2English
OctrooinummerWO03099862
Prioriteitsdatum24/05/2002
Indieningsdatum26/05/2003
StatusPublished - 4-dec-2003

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