Export and modification of (poly)peptides in the lantibiotic way

Gert Nikolaas Moll; Cornelis Johannes Leenhouts; Oscar Paul Kuipers; Arnold Jacob Mathieu Driessen

Export and modification of (poly)peptides in the lantibiotic way

Gert Nikolaas Moll (Uitvinder), Cornelis Johannes Leenhouts (Uitvinder), Oscar Paul Kuipers (Uitvinder), Arnold Jacob Mathieu Driessen (Uitvinder)

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The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine-containing peptides, wherein extracellularly thioether rings may be formed.

Originele taal-2	English
Octrooinummer	WO03099862
Prioriteitsdatum	24/05/2002
Indieningsdatum	26/05/2003
Status	Published - 4-dec.-2003

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WO200399862_A1Final publisher's version, 4,7 MB

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title = "Export and modification of (poly)peptides in the lantibiotic way",

abstract = "The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine-containing peptides, wherein extracellularly thioether rings may be formed.",

author = "Moll, {Gert Nikolaas} and Leenhouts, {Cornelis Johannes} and Kuipers, {Oscar Paul} and Driessen, {Arnold Jacob Mathieu}",

year = "2003",

month = dec,

day = "4",

language = "English",

type = "Patent",

note = "WO03099862",

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TY - PAT

T1 - Export and modification of (poly)peptides in the lantibiotic way

AU - Moll, Gert Nikolaas

AU - Leenhouts, Cornelis Johannes

AU - Kuipers, Oscar Paul

AU - Driessen, Arnold Jacob Mathieu

PY - 2003/12/4

Y1 - 2003/12/4

N2 - The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine-containing peptides, wherein extracellularly thioether rings may be formed.

AB - The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioether bridge formation. The invention also includes a method for producing thioether containing peptides and dehydroalanine/dehydrobutyrine-containing peptides, wherein extracellularly thioether rings may be formed.

M3 - Patent

M1 - WO03099862

Y2 - 2003/05/26

ER -