TY - JOUR
T1 - Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits
AU - van der Meer, Thomas P.
AU - van Faassen, Martijn
AU - van Beek, Andre P.
AU - Snieder, Harold
AU - Kema, Ido P.
AU - Wolffenbuttel, Bruce H. R.
AU - van Vliet-Ostaptchouk, Jana V.
PY - 2020/6/9
Y1 - 2020/6/9
N2 - Endocrine Disrupting Chemicals (EDCs) have been linked to a variety of cardiometabolic diseases. Yet, few studies have investigated the exposure to EDCs and cardiometabolic health taking lifestyle into account. We aimed to assess exposure to five parabens, three bisphenols and thirteen metabolites of in total eight phthalates in a general Dutch population and to investigate their association with cardiometabolic traits. In 662 adult subjects from the population-based Lifelines cohort, 21 EDC analytes were measured in 24-hour urine collected in 2012, using LC-MS/MS. Association analyses between cardiometabolic traits and EDC concentrations were performed using multivariate linear models adjusting for age, sex, education, smoking, diabetes, physical activity and caloric intake. Quartile analyses were performed to assess linearity. Bisphenol A, four parabens and eight phthalate metabolites were detected in 84-100% of the samples. Adjusted associations for MiBP and MBzP and adiposity-related traits were robust for multiple testing (Beta's, BMI: 1.12, 2.52; waist circumference: 0.64, 1.56, respectively; FDR
AB - Endocrine Disrupting Chemicals (EDCs) have been linked to a variety of cardiometabolic diseases. Yet, few studies have investigated the exposure to EDCs and cardiometabolic health taking lifestyle into account. We aimed to assess exposure to five parabens, three bisphenols and thirteen metabolites of in total eight phthalates in a general Dutch population and to investigate their association with cardiometabolic traits. In 662 adult subjects from the population-based Lifelines cohort, 21 EDC analytes were measured in 24-hour urine collected in 2012, using LC-MS/MS. Association analyses between cardiometabolic traits and EDC concentrations were performed using multivariate linear models adjusting for age, sex, education, smoking, diabetes, physical activity and caloric intake. Quartile analyses were performed to assess linearity. Bisphenol A, four parabens and eight phthalate metabolites were detected in 84-100% of the samples. Adjusted associations for MiBP and MBzP and adiposity-related traits were robust for multiple testing (Beta's, BMI: 1.12, 2.52; waist circumference: 0.64, 1.56, respectively; FDR
KW - URINARY PHTHALATE METABOLITES
KW - BISPHENOL-A CONCENTRATION
KW - DUISBURG BIRTH COHORT
KW - MOTHER-CHILD-PAIRS
KW - PREGNANT-WOMEN
KW - ENVIRONMENTAL CHEMICALS
KW - INSULIN-RESISTANCE
KW - TEMPORAL TRENDS
KW - PARABENS
KW - EXCRETION
U2 - 10.1038/s41598-020-66284-3
DO - 10.1038/s41598-020-66284-3
M3 - Article
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 9311
ER -