Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade

R Komdeur; B E C Plaat; W T A van der Graaf; H. J. Hoekstra; H Hollema; E. van den Berg; N Zwart; R J Scheper; W M Molenaar

doi:10.1016/S0959-8049(03)00029-7

Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade

R Komdeur, B E C Plaat, W T A van der Graaf, H. J. Hoekstra, H Hollema, E. van den Berg, N Zwart, R J Scheper, W M Molenaar

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The biological behaviour of different histological types and grades of soft tissue sarcomas (STS) varies. This might result in a differing sensitivity to cytotoxic drugs. Cross-resistance to functionally and structurally distinct natural-product drugs, known as multidrug resistance (MDR), is associated with the overexpression of P-glycoprotein (P-gp), multidrug resistance-associated protein I (MRP1) and lung resistance-related protein (LRP). The purpose of this study was to evaluate the expression of P-gp, MRP1 and LRP in STS according to their histological type and grade. In 141 chemotherapy-naive STS patients, the expression of the three MDR proteins was detected by immunohistochemistry. Nine histological types were documented. These were 19% grade 1, 34% grade 2 and 47% grade 3 tumours. Expression of P-gp and LRP was observed more frequently than the expression of MRP1 (P

Originele taal-2	English
Pagina's (van-tot)	909-916
Aantal pagina's	8
Tijdschrift	European Journal of Cancer
Volume	39
Nummer van het tijdschrift	7
DOI's	https://doi.org/10.1016/S0959-8049(03)00029-7
Status	Published - mei-2003

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Komdeur, R., Plaat, B. E. C., van der Graaf, W. T. A., Hoekstra, H. J., Hollema, H., van den Berg, E., Zwart, N., Scheper, R. J., & Molenaar, W. M. (2003). Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade. European Journal of Cancer, 39(7), 909-916. https://doi.org/10.1016/S0959-8049(03)00029-7

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title = "Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade",

abstract = "The biological behaviour of different histological types and grades of soft tissue sarcomas (STS) varies. This might result in a differing sensitivity to cytotoxic drugs. Cross-resistance to functionally and structurally distinct natural-product drugs, known as multidrug resistance (MDR), is associated with the overexpression of P-glycoprotein (P-gp), multidrug resistance-associated protein I (MRP1) and lung resistance-related protein (LRP). The purpose of this study was to evaluate the expression of P-gp, MRP1 and LRP in STS according to their histological type and grade. In 141 chemotherapy-naive STS patients, the expression of the three MDR proteins was detected by immunohistochemistry. Nine histological types were documented. These were 19% grade 1, 34% grade 2 and 47% grade 3 tumours. Expression of P-gp and LRP was observed more frequently than the expression of MRP1 (P",

keywords = "multidrug resistance, P-gp, MRP1, LRP, sarcoma, GASTROINTESTINAL STROMAL TUMORS, PROGNOSTIC FACTORS, GLYCOPROTEIN EXPRESSION, EUROPEAN-ORGANIZATION, DRUG-RESISTANCE, VAULT PROTEIN, CELL-LINES, CANCER, CHEMOTHERAPY, DOXORUBICIN",

author = "R Komdeur and Plaat, {B E C} and {van der Graaf}, {W T A} and Hoekstra, {H. J.} and H Hollema and {van den Berg}, E. and N Zwart and Scheper, {R J} and Molenaar, {W M}",

year = "2003",

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Komdeur, R, Plaat, BEC, van der Graaf, WTA, Hoekstra, HJ, Hollema, H, van den Berg, E, Zwart, N, Scheper, RJ & Molenaar, WM 2003, 'Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade', European Journal of Cancer, vol. 39, nr. 7, blz. 909-916. https://doi.org/10.1016/S0959-8049(03)00029-7

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AU - Komdeur, R

AU - Plaat, B E C

AU - van der Graaf, W T A

AU - Hoekstra, H. J.

AU - Hollema, H

AU - van den Berg, E.

AU - Zwart, N

AU - Scheper, R J

AU - Molenaar, W M

PY - 2003/5

Y1 - 2003/5

N2 - The biological behaviour of different histological types and grades of soft tissue sarcomas (STS) varies. This might result in a differing sensitivity to cytotoxic drugs. Cross-resistance to functionally and structurally distinct natural-product drugs, known as multidrug resistance (MDR), is associated with the overexpression of P-glycoprotein (P-gp), multidrug resistance-associated protein I (MRP1) and lung resistance-related protein (LRP). The purpose of this study was to evaluate the expression of P-gp, MRP1 and LRP in STS according to their histological type and grade. In 141 chemotherapy-naive STS patients, the expression of the three MDR proteins was detected by immunohistochemistry. Nine histological types were documented. These were 19% grade 1, 34% grade 2 and 47% grade 3 tumours. Expression of P-gp and LRP was observed more frequently than the expression of MRP1 (P

AB - The biological behaviour of different histological types and grades of soft tissue sarcomas (STS) varies. This might result in a differing sensitivity to cytotoxic drugs. Cross-resistance to functionally and structurally distinct natural-product drugs, known as multidrug resistance (MDR), is associated with the overexpression of P-glycoprotein (P-gp), multidrug resistance-associated protein I (MRP1) and lung resistance-related protein (LRP). The purpose of this study was to evaluate the expression of P-gp, MRP1 and LRP in STS according to their histological type and grade. In 141 chemotherapy-naive STS patients, the expression of the three MDR proteins was detected by immunohistochemistry. Nine histological types were documented. These were 19% grade 1, 34% grade 2 and 47% grade 3 tumours. Expression of P-gp and LRP was observed more frequently than the expression of MRP1 (P

KW - multidrug resistance

KW - P-gp

KW - MRP1

KW - LRP

KW - sarcoma

KW - GASTROINTESTINAL STROMAL TUMORS

KW - PROGNOSTIC FACTORS

KW - GLYCOPROTEIN EXPRESSION

KW - EUROPEAN-ORGANIZATION

KW - DRUG-RESISTANCE

KW - VAULT PROTEIN

KW - CELL-LINES

KW - CANCER

KW - CHEMOTHERAPY

KW - DOXORUBICIN

U2 - 10.1016/S0959-8049(03)00029-7

DO - 10.1016/S0959-8049(03)00029-7

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C2 - 12706359

SN - 0959-8049

VL - 39

SP - 909

EP - 916

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 7

ER -

Expression of multidrug resistance proteins, P-gp, MRP1 and LRP, in soft tissue sarcomas analysed according to their histological type and grade

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