TY - JOUR
T1 - Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [18F]FDG-PET (PETMETPAT)
T2 - Working Group Summaries for European Joint Programming For Neurodegenerative Research (JPND)
AU - Kogan, Rosalie Vered
AU - Jong, de, Bas Adriaan
AU - Renken, Remco J.
AU - Meles, Sanne K.
AU - van Snick, Paul J. H.
AU - Golla, Sandeep
AU - Rijnsdorp, Sjoerd
AU - Perani, Daniela
AU - Leenders, Klaus L.
AU - Boellaard, Ronald
PY - 2019
Y1 - 2019
N2 - Introduction:The implementation of spatial-covariance [18F]fluorodeoxyglucose positron emissiontomography–based disease-related metabolic brain patterns as biomarkers has been hampered by in-tercenter imaging differences. Within the scope of the JPND-PETMETPAT working group, we illus-trate the impact of these differences on Parkinson’s disease–related pattern (PDRP) expressionscores.Methods:Five healthy controls, 5 patients with idiopathic rapid eye movement sleep behavior dis-order, and 5 patients with Parkinson’s disease were scanned on one positron emission tomography/computed tomography system with multiple image reconstructions. In addition, one Hoffman 3DBrain Phantom was scanned on several positron emission tomography/computed tomography sys-tems using various reconstructions. Effects of image contrast on PDRP scores were also examined.Results:Human and phantom raw PDRP scores were systematically influenced by scanner andreconstruction effects. PDRP scores correlated inversely to image contrast. A Gaussian spatial filterreduced contrast while decreasing intercenter score differences.Discussion:Image contrast should be considered in harmonization efforts. A Gaussian filter mayreduce noise and intercenter effects without sacrificing sensitivity. Phantom measurements will beimportant for correcting PDRP score offsets.
AB - Introduction:The implementation of spatial-covariance [18F]fluorodeoxyglucose positron emissiontomography–based disease-related metabolic brain patterns as biomarkers has been hampered by in-tercenter imaging differences. Within the scope of the JPND-PETMETPAT working group, we illus-trate the impact of these differences on Parkinson’s disease–related pattern (PDRP) expressionscores.Methods:Five healthy controls, 5 patients with idiopathic rapid eye movement sleep behavior dis-order, and 5 patients with Parkinson’s disease were scanned on one positron emission tomography/computed tomography system with multiple image reconstructions. In addition, one Hoffman 3DBrain Phantom was scanned on several positron emission tomography/computed tomography sys-tems using various reconstructions. Effects of image contrast on PDRP scores were also examined.Results:Human and phantom raw PDRP scores were systematically influenced by scanner andreconstruction effects. PDRP scores correlated inversely to image contrast. A Gaussian spatial filterreduced contrast while decreasing intercenter score differences.Discussion:Image contrast should be considered in harmonization efforts. A Gaussian filter mayreduce noise and intercenter effects without sacrificing sensitivity. Phantom measurements will beimportant for correcting PDRP score offsets.
KW - Neuroimaging biomarker
KW - FDG-PET
KW - Harmonization
KW - Hoffman 3D brain phantom
KW - Principal Component Analysis
U2 - 10.1016/j.dadm.2019.04.002
DO - 10.1016/j.dadm.2019.04.002
M3 - Article
SN - 2352-8729
VL - 11
SP - 472
EP - 482
JO - Alzheimer's & dementia (Amsterdam, Netherlands)
JF - Alzheimer's & dementia (Amsterdam, Netherlands)
ER -