Samenvatting
Background: beta(2)-Adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies.
Objective: We sought to apply family-based association methods to individual single nucleotide polymorphisms (SNPs) and haplotypes of SNPs in B2AR to define the relationship of these genetic variants to asthma-related phenotypes.
Methods: DNA samples were obtained from 707 Childhood Asthma Management Program participants, representing 650 sibships, as well as their parents. Genotyping was performed at 8 B2AR SNPs. Qualitative asthma-related phenotypes were analyzed with single SNPs and haplotypes by using TRANSMIT; quantitative asthma-related phenotypes were analyzed with the Family-Based Association Test.
Results: Several SNPs, including SNP -654 and SNP +46, demonstrated significant associations (P
Conclusion: B2AR variants are associated with spirometric values and bronchodilator responsiveness, but different regions of the gene provide evidence for association with these phenotypes.
| Originele taal-2 | English |
|---|---|
| Pagina's (van-tot) | 870-876 |
| Aantal pagina's | 7 |
| Tijdschrift | Journal of Allergy and Clinical Immunology |
| Volume | 112 |
| Nummer van het tijdschrift | 5 |
| DOI's | |
| Status | Published - nov.-2003 |