FDG-PET-CT reduces the interobserver variability in rectal tumor delineation

Jeroen Buijsen*, Jørgen van den Bogaard, Hiska van der Weide, Stephanie Engelsman, Ruud van Stiphout, Marco Janssen, Geerard Beets, Regina Beets-Tan, Philippe Lambin, Guido Lammering

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

44 Citaten (Scopus)


BACKGROUND AND PURPOSE: Previously, we showed a good correlation between pathology and an automatically generated PET-contour in rectal cancer. This study analyzed the effect of the use of PET-CT scan on the interobserver variation in GTV definition in rectal cancer and the influence of PET-CT on treatment volumes.

MATERIALS AND METHODS: Forty two patients diagnosed with rectal cancer underwent an FDG-PET-CT for radiotherapy planning. An automatic contour was created on PET-scan using the source-to-background ratio. The GTV was delineated by 5 observers in 3 rounds: using CT and MRI, using CT, MRI and PET and using CT, MRI and PET auto-contour. GTV volumes were compared and concordance indices (CI) were calculated. Since the GTV is only a small portion of the treatment volume in rectal cancer, a separate analysis was performed to evaluate the influence of PET on the definition of the CTV used in daily clinical practice and the caudal extension of the treatment volumes.

RESULTS: GTV volumes based on PET were significantly smaller. CIs increased significantly using PET and the best interobserver agreement was observed using PET auto-contours. Furthermore, we found that in up to 29% of patients the CTV based on PET extended outside the CTV used in clinical practice. The caudal border of the treatment volume can be tailored using PET-scan in low seated tumors. Influence of PET on the position of the caudal border was most pronounced in high seated tumors.

CONCLUSION: PET-CT increases the interobserver agreement in the GTV definition in rectal cancer, helps to avoid geographical misses and allows tailoring the caudal border of the treatment volume.

Originele taal-2English
Pagina's (van-tot)371-6
Aantal pagina's6
TijdschriftRadiotherapy and Oncology
Nummer van het tijdschrift3
StatusPublished - mrt-2012
Extern gepubliceerdJa

Citeer dit