Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)

Natalia Oiring de Castro Cezar; Ivan Aprahamian; Juliana Hotta; Marcos Paulo Braz de Oliveira; Danielle Chagas Pereira da Silva; Wildja de Lima Gomes; Bruna Anzolin Barreiros; Tamiris de Cassia Oliva Langelli; Larissa Pires de Andrade

doi:10.1016/j.exger.2021.111390

Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)

Natalia Oiring de Castro Cezar^*, Ivan Aprahamian, Juliana Hotta, Marcos Paulo Braz de Oliveira, Danielle Chagas Pereira da Silva, Wildja de Lima Gomes, Bruna Anzolin Barreiros, Tamiris de Cassia Oliva Langelli, Larissa Pires de Andrade

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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Objectives: There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was to investigate the effect of a home-based multimodal exercise program for older adults with AD (AD-HOMEX) on frailty.

Design: A parallel single-blind randomized controlled trial comparing a home-based exercise program and usual care.

Setting and participants: A home-based program in Brazil. Forty individuals aged 65 years or older with mild to moderate AD.

Methods: The intervention group (IG) participated in a 16-week protocol involving three 60-minute sessions per week of progressive individualized physical exercises supervised by a physical therapist. The participants in the control group (CG) maintained their usual care. Frailty was assessed using the FRAIL questionnaire, the Edmonton Frail Scale (EFS) and a subjective assessment by the evaluator (SAE) at baseline and follow-up. Per-protocol analysis was performed.

Results: Thirty-five participants completed the program (IG = 16; CG = 19). Frailty improved in the IG based on the EFS (P = .004) and FRAIL (P

Conclusions and implications: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.

Originele taal-2	English
Artikelnummer	111390
Pagina's (van-tot)	1-8
Aantal pagina's	8
Tijdschrift	Experimental Gerontology
Volume	150
DOI's	https://doi.org/10.1016/j.exger.2021.111390
Status	Published - 15-jul.-2021

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Feasibility of reducing frailty components in older adults with Alzheimer's dementia- a randomized controlled home-based exercise trial (AD-HOMEX)Final publisher's version, 1,86 MBLicentie: Taverne

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Cezar, N. O. D. C., Aprahamian, I., Hotta, J., de Oliveira, M. P. B., da Silva, D. C. P., Gomes, W. D. L., Barreiros, B. A., Langelli, T. D. C. O., & Andrade, L. P. D. (2021). Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX). Experimental Gerontology, 150, 1-8. Artikel 111390. https://doi.org/10.1016/j.exger.2021.111390

@article{bd7cf53030e54f388016e8a5ce63da00,

title = "Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)",

abstract = "Objectives: There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was to investigate the effect of a home-based multimodal exercise program for older adults with AD (AD-HOMEX) on frailty.Design: A parallel single-blind randomized controlled trial comparing a home-based exercise program and usual care.Setting and participants: A home-based program in Brazil. Forty individuals aged 65 years or older with mild to moderate AD.Methods: The intervention group (IG) participated in a 16-week protocol involving three 60-minute sessions per week of progressive individualized physical exercises supervised by a physical therapist. The participants in the control group (CG) maintained their usual care. Frailty was assessed using the FRAIL questionnaire, the Edmonton Frail Scale (EFS) and a subjective assessment by the evaluator (SAE) at baseline and follow-up. Per-protocol analysis was performed.Results: Thirty-five participants completed the program (IG = 16; CG = 19). Frailty improved in the IG based on the EFS (P = .004) and FRAIL (PConclusions and implications: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.",

keywords = "Physical activity, Exercise, Alzheimer's, Frailty, Home-based, Randomized controlled trial, COGNITIVE IMPAIRMENT, SOCIAL DESIRABILITY, DISEASE, INTERVENTION, PEOPLE, MILD, PROGRAM, PERFORMANCE, MOBILITY, BALANCE",

author = "Cezar, {Natalia Oiring de Castro} and Ivan Aprahamian and Juliana Hotta and {de Oliveira}, {Marcos Paulo Braz} and {da Silva}, {Danielle Chagas Pereira} and Gomes, {Wildja de Lima} and Barreiros, {Bruna Anzolin} and Langelli, {Tamiris de Cassia Oliva} and Andrade, {Larissa Pires de}",

year = "2021",

month = jul,

day = "15",

doi = "10.1016/j.exger.2021.111390",

language = "English",

volume = "150",

pages = "1--8",

journal = "Experimental Gerontology",

issn = "0531-5565",

publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

Cezar, NODC, Aprahamian, I, Hotta, J, de Oliveira, MPB, da Silva, DCP, Gomes, WDL, Barreiros, BA, Langelli, TDCO & Andrade, LPD 2021, 'Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)', Experimental Gerontology, vol. 150, 111390, blz. 1-8. https://doi.org/10.1016/j.exger.2021.111390

TY - JOUR

T1 - Feasibility of reducing frailty components in older adults with Alzheimer's dementia

T2 - a randomized controlled home-based exercise trial (AD-HOMEX)

AU - Cezar, Natalia Oiring de Castro

AU - Aprahamian, Ivan

AU - Hotta, Juliana

AU - de Oliveira, Marcos Paulo Braz

AU - da Silva, Danielle Chagas Pereira

AU - Gomes, Wildja de Lima

AU - Barreiros, Bruna Anzolin

AU - Langelli, Tamiris de Cassia Oliva

AU - Andrade, Larissa Pires de

PY - 2021/7/15

Y1 - 2021/7/15

N2 - Objectives: There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was to investigate the effect of a home-based multimodal exercise program for older adults with AD (AD-HOMEX) on frailty.Design: A parallel single-blind randomized controlled trial comparing a home-based exercise program and usual care.Setting and participants: A home-based program in Brazil. Forty individuals aged 65 years or older with mild to moderate AD.Methods: The intervention group (IG) participated in a 16-week protocol involving three 60-minute sessions per week of progressive individualized physical exercises supervised by a physical therapist. The participants in the control group (CG) maintained their usual care. Frailty was assessed using the FRAIL questionnaire, the Edmonton Frail Scale (EFS) and a subjective assessment by the evaluator (SAE) at baseline and follow-up. Per-protocol analysis was performed.Results: Thirty-five participants completed the program (IG = 16; CG = 19). Frailty improved in the IG based on the EFS (P = .004) and FRAIL (PConclusions and implications: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.

AB - Objectives: There is a need for interventions to reduce frailty in older people with Alzheimer's dementia (AD). The purpose of this study was to investigate the effect of a home-based multimodal exercise program for older adults with AD (AD-HOMEX) on frailty.Design: A parallel single-blind randomized controlled trial comparing a home-based exercise program and usual care.Setting and participants: A home-based program in Brazil. Forty individuals aged 65 years or older with mild to moderate AD.Methods: The intervention group (IG) participated in a 16-week protocol involving three 60-minute sessions per week of progressive individualized physical exercises supervised by a physical therapist. The participants in the control group (CG) maintained their usual care. Frailty was assessed using the FRAIL questionnaire, the Edmonton Frail Scale (EFS) and a subjective assessment by the evaluator (SAE) at baseline and follow-up. Per-protocol analysis was performed.Results: Thirty-five participants completed the program (IG = 16; CG = 19). Frailty improved in the IG based on the EFS (P = .004) and FRAIL (PConclusions and implications: AD-HOMEX seems to reduce frailty and improve frailty transition patterns. Our findings provide a further theoretical basis for designing home-based physical interventions as routine practice for older frail adults with AD.

KW - Physical activity

KW - Exercise

KW - Alzheimer's

KW - Frailty

KW - Home-based

KW - Randomized controlled trial

KW - COGNITIVE IMPAIRMENT

KW - SOCIAL DESIRABILITY

KW - DISEASE

KW - INTERVENTION

KW - PEOPLE

KW - MILD

KW - PROGRAM

KW - PERFORMANCE

KW - MOBILITY

KW - BALANCE

U2 - 10.1016/j.exger.2021.111390

DO - 10.1016/j.exger.2021.111390

M3 - Article

SN - 0531-5565

VL - 150

SP - 1

EP - 8

JO - Experimental Gerontology

JF - Experimental Gerontology

M1 - 111390

ER -

Feasibility of reducing frailty components in older adults with Alzheimer's dementia: a randomized controlled home-based exercise trial (AD-HOMEX)

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