Feedforward control of agonist-induced Ca2+ signalling by protein kinase C in airway smooth muscle cells

B.H. Hoiting*, R. Kuipers, C.R.S. Elzinga, J. Zaagsma, H. Meurs

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

9 Citaten (Scopus)


In isolated bovine tracheal smooth muscle cells, the potent and specific protein kinase C inhibitor GF 109203X caused an inhibition of methacholine-and histamine-induced Ca2+ mobilization and influx, indicating for the first time that protein kinase C activation induced by contractile agonists exerts a positive feedforward control of Ca2+ signalling by these agonists.

Originele taal-2English
Pagina's (van-tot)R5-R7
Aantal pagina's3
TijdschriftEuropean journal of pharmacology-Molecular pharmacology section
Nummer van het tijdschrift2
StatusPublished - 18-jul-1995

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