Finding new edges: systems approaches to MTOR signaling

Alexander Martin Heberle, Ulrike Rehbein, Maria Rodríguez Peiris, Kathrin Thedieck*

*Bijbehorende auteur voor dit werk

    Onderzoeksoutput: Review articlepeer review

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    Cells have evolved highly intertwined kinase networks to finely tune cellular homeostasis to the environment. The network converging on the mechanistic target of rapamycin (MTOR) kinase constitutes a central hub that integrates metabolic signals and adapts cellular metabolism and functions to nutritional changes and stress. Feedforward and feedback loops, crosstalks and a plethora of modulators finely balance MTOR-driven anabolic and catabolic processes. This complexity renders it difficult - if not impossible - to intuitively decipher signaling dynamics and network topology. Over the last two decades, systems approaches have emerged as powerful tools to simulate signaling network dynamics and responses. In this review, we discuss the contribution of systems studies to the discovery of novel edges and modulators in the MTOR network in healthy cells and in disease.

    Originele taal-2English
    Pagina's (van-tot)41-54
    Aantal pagina's14
    TijdschriftBiochemical Society Transactions
    Nummer van het tijdschrift1
    Vroegere onlinedatum5-feb.-2021
    StatusPublished - feb.-2021

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