Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

Harm-Jan Westra; Marta Martinez-Bonet; Suna Onengut-Gumuscu; Annette Lee; Yang Luol; Nikola Teslovich; Jane Worthington; Javier Martin; Tom Huizinga; Lars Klareskog; Solbritt Rantapaa-Dahlqvist; Wei-Min Chen; Aaron Quinlan; John A. Todd; Steve Eyre; Peter A. Nigrovic; Peter K. G. Regersen; Stephen S. Rich; Soumya Raychaudhuri

doi:10.1038/s41588-018-0216-7

Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

Harm-Jan Westra, Marta Martinez-Bonet, Suna Onengut-Gumuscu, Annette Lee, Yang Luol, Nikola Teslovich, Jane Worthington, Javier Martin, Tom Huizinga, Lars Klareskog, Solbritt Rantapaa-Dahlqvist, Wei-Min Chen, Aaron Quinlan, John A. Todd, Steve Eyre, Peter A. Nigrovic, Peter K. G. Regersen, Stephen S. Rich, Soumya Raychaudhuri^*

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput › Academic › peer review

73 Citaten (Scopus)

Samenvatting

To define potentially causal variants for autoimmune disease, we fine-mapped(1,2) 76 rheumatoid arthritis (11,475 cases,15,870 controls)(3) and type 1 diabetes loci (9,334 cases, 11,111 controls)(4). After sequencing 799 1-kilobase regulatory (H3K4me3) regions within these loci in 568 individuals, we observed accurate imputation for 89% of common variants. We defined credible sets of

Originele taal-2	English
Pagina's (van-tot)	1366-1374
Aantal pagina's	12
Tijdschrift	Nature Genetics
Volume	50
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1038/s41588-018-0216-7
Status	Published - okt-2018

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10.1038/s41588-018-0216-7

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364548Licentie: Unspecified

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Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
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Westra, H-J., Martinez-Bonet, M., Onengut-Gumuscu, S., Lee, A., Luol, Y., Teslovich, N., Worthington, J., Martin, J., Huizinga, T., Klareskog, L., Rantapaa-Dahlqvist, S., Chen, W-M., Quinlan, A., Todd, J. A., Eyre, S., Nigrovic, P. A., Regersen, P. K. G., Rich, S. S., & Raychaudhuri, S. (2018). Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. Nature Genetics, 50(10), 1366-1374. https://doi.org/10.1038/s41588-018-0216-7

Westra, Harm-Jan ; Martinez-Bonet, Marta ; Onengut-Gumuscu, Suna ; Lee, Annette ; Luol, Yang ; Teslovich, Nikola ; Worthington, Jane ; Martin, Javier ; Huizinga, Tom ; Klareskog, Lars ; Rantapaa-Dahlqvist, Solbritt ; Chen, Wei-Min ; Quinlan, Aaron ; Todd, John A. ; Eyre, Steve ; Nigrovic, Peter A. ; Regersen, Peter K. G. ; Rich, Stephen S. ; Raychaudhuri, Soumya. / Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. In: Nature Genetics. 2018 ; Vol. 50, Nr. 10. blz. 1366-1374.

@article{55e4a5ebeb734f8699c6af09001a8d83,

title = "Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes",

abstract = "To define potentially causal variants for autoimmune disease, we fine-mapped(1,2) 76 rheumatoid arthritis (11,475 cases,15,870 controls)(3) and type 1 diabetes loci (9,334 cases, 11,111 controls)(4). After sequencing 799 1-kilobase regulatory (H3K4me3) regions within these loci in 568 individuals, we observed accurate imputation for 89% of common variants. We defined credible sets of",

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author = "Harm-Jan Westra and Marta Martinez-Bonet and Suna Onengut-Gumuscu and Annette Lee and Yang Luol and Nikola Teslovich and Jane Worthington and Javier Martin and Tom Huizinga and Lars Klareskog and Solbritt Rantapaa-Dahlqvist and Wei-Min Chen and Aaron Quinlan and Todd, {John A.} and Steve Eyre and Nigrovic, {Peter A.} and Regersen, {Peter K. G.} and Rich, {Stephen S.} and Soumya Raychaudhuri",

year = "2018",

month = oct,

doi = "10.1038/s41588-018-0216-7",

language = "English",

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Westra, H-J, Martinez-Bonet, M, Onengut-Gumuscu, S, Lee, A, Luol, Y, Teslovich, N, Worthington, J, Martin, J, Huizinga, T, Klareskog, L, Rantapaa-Dahlqvist, S, Chen, W-M, Quinlan, A, Todd, JA, Eyre, S, Nigrovic, PA, Regersen, PKG, Rich, SS & Raychaudhuri, S 2018, 'Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes', Nature Genetics, vol. 50, nr. 10, blz. 1366-1374. https://doi.org/10.1038/s41588-018-0216-7

Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. / Westra, Harm-Jan; Martinez-Bonet, Marta; Onengut-Gumuscu, Suna; Lee, Annette; Luol, Yang; Teslovich, Nikola; Worthington, Jane; Martin, Javier; Huizinga, Tom; Klareskog, Lars; Rantapaa-Dahlqvist, Solbritt; Chen, Wei-Min; Quinlan, Aaron; Todd, John A.; Eyre, Steve; Nigrovic, Peter A.; Regersen, Peter K. G.; Rich, Stephen S.; Raychaudhuri, Soumya.

In: Nature Genetics, Vol. 50, Nr. 10, 10.2018, blz. 1366-1374.

Onderzoeksoutput › Academic › peer review

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AU - Martinez-Bonet, Marta

AU - Onengut-Gumuscu, Suna

AU - Lee, Annette

AU - Luol, Yang

AU - Teslovich, Nikola

AU - Worthington, Jane

AU - Martin, Javier

AU - Huizinga, Tom

AU - Klareskog, Lars

AU - Rantapaa-Dahlqvist, Solbritt

AU - Chen, Wei-Min

AU - Quinlan, Aaron

AU - Todd, John A.

AU - Eyre, Steve

AU - Nigrovic, Peter A.

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AU - Raychaudhuri, Soumya

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