Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes

Harm-Jan Westra, Marta Martinez-Bonet, Suna Onengut-Gumuscu, Annette Lee, Yang Luol, Nikola Teslovich, Jane Worthington, Javier Martin, Tom Huizinga, Lars Klareskog, Solbritt Rantapaa-Dahlqvist, Wei-Min Chen, Aaron Quinlan, John A. Todd, Steve Eyre, Peter A. Nigrovic, Peter K. G. Regersen, Stephen S. Rich, Soumya Raychaudhuri*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    73 Citaten (Scopus)

    Samenvatting

    To define potentially causal variants for autoimmune disease, we fine-mapped(1,2) 76 rheumatoid arthritis (11,475 cases,15,870 controls)(3) and type 1 diabetes loci (9,334 cases, 11,111 controls)(4). After sequencing 799 1-kilobase regulatory (H3K4me3) regions within these loci in 568 individuals, we observed accurate imputation for 89% of common variants. We defined credible sets of

    Originele taal-2English
    Pagina's (van-tot)1366-1374
    Aantal pagina's12
    TijdschriftNature Genetics
    Volume50
    Nummer van het tijdschrift10
    DOI's
    StatusPublished - okt-2018

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