Fine mapping of the human renal oncocytoma-associated translocation (5;11)(q35;q13) breakpoint

RJ Sinke, T Dijkhuizen, B Janssen, DO Weghuis, G Merkx, E vandenBerg, E Schuuring, AM Meloni, B deJong, AG vanKessel

OnderzoeksoutputAcademicpeer review

31 Citaten (Scopus)


Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;11)(q35;q13) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;11)-positive renal oncocytomas and a panel of somatic cell hybrids derived from one of these tumors, in conjunction with fluorescence in situ hybridization (FISH) and Southern blot analysis. The breakpoint in chromosome band 11q13 could be located within a genomic interval of at maximum 400 Kb immediately centromeric to the BCL1 locus. (C) Elsevier Science Inc., 1997.

Originele taal-2English
Pagina's (van-tot)95-101
Aantal pagina's7
TijdschriftCancer Genetics and Cytogenetics
Nummer van het tijdschrift2
StatusPublished - 15-jul-1997

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