TY - JOUR
T1 - Flavin-Dependent Nitroreductases
T2 - Privileged Enzymes for Chemical and Photochemical Synthesis
AU - Russo, Sara
AU - Luján, Alejandro Prats
AU - Fraaije, Marco W.
AU - Poelarends, Gerrit J.
N1 - Publisher Copyright:
© 2024 The Author(s). ChemCatChem published by Wiley-VCH GmbH.
PY - 2024/12/2
Y1 - 2024/12/2
N2 - Nitroreductases, present within both prokaryotes and eukaryotes, form a group of flavin-dependent enzymes capable of reducing nitro compounds using NAD(P)H as reducing agent. These enzymes have been widely studied due to their diverse roles in bioremediation, cancer therapy, cell ablation, and antimicrobial resistance. In recent times, the versatility of nitroreductases has been expanded toward the synthesis of highly valuable compounds such as aromatic and aliphatic amines, azoxy and azobenzenes, as well as N-heterocycles. This review examines the biological role and diversity of flavin-dependent nitroreductases, and highlights their current and potential future application as biocatalysts for the sustainable synthesis of nitrogen-containing pharmaceutical compounds and bulk chemicals.
AB - Nitroreductases, present within both prokaryotes and eukaryotes, form a group of flavin-dependent enzymes capable of reducing nitro compounds using NAD(P)H as reducing agent. These enzymes have been widely studied due to their diverse roles in bioremediation, cancer therapy, cell ablation, and antimicrobial resistance. In recent times, the versatility of nitroreductases has been expanded toward the synthesis of highly valuable compounds such as aromatic and aliphatic amines, azoxy and azobenzenes, as well as N-heterocycles. This review examines the biological role and diversity of flavin-dependent nitroreductases, and highlights their current and potential future application as biocatalysts for the sustainable synthesis of nitrogen-containing pharmaceutical compounds and bulk chemicals.
KW - Biocatalysis
KW - Enzyme engineering
KW - Nitroreductases
KW - Pharmaceutical synthesis
UR - http://www.scopus.com/inward/record.url?scp=85213406725&partnerID=8YFLogxK
U2 - 10.1002/cctc.202401304
DO - 10.1002/cctc.202401304
M3 - Review article
AN - SCOPUS:85213406725
SN - 1867-3880
JO - ChemCatChem
JF - ChemCatChem
M1 - e202401304
ER -