Fluorescence mesoscopic imaging of whole lymph nodes for intraoperative sentinel lymph node biopsy procedures

Kenneth M. Tichauer, Cody Rounds, Veronica C. Torres, Chengyue Li, Hang Nguyen, Thom S. Nijboer, Floris J. Voskuil, Jovan G. Brankov, Max J. H. Witjes

OnderzoeksoutputAcademicpeer review


An increasing number of cancer surgery protocols are including sentinel lymph node biopsies on the day of resection to stage for non-palpable spread of cancer through tumor draining lymph nodes. The challenge is that often a tumor-positive node will make it necessary to perform an enhanced resection of the lymphatic network, and if lymph node processing is not completed within the timeframe of surgery, then patients may have to be called back for additional surgery or have to undergo amplified chemo or radiation therapy. Our group is working on a rapid lymph node staining and fluorescence tomography system that we call ADEPT to provide surgeons with lymph node biopsy results within 15 min. The aim is to minimize the number of callback surgery or amplified therapy procedures to minimize stress to patients and reduce health care costs. This work predicts, using Monte Carlo photon propagation modeling simulations, that ADEPT has the potential to yield greater than 95% accuracy in detecting the smallest amount of cancer considered clinically relevant withing 15 min of tissue processing and imaging.

Originele taal-2English
TitelMolecular-Guided Surgery
SubtitelMolecules, Devices, and Applications IX
RedacteurenSylvain Gioux, Summer L. Gibbs, Brian W. Pogue
ISBN van elektronische versie9781510658271
StatusPublished - 2023
EvenementMolecular-Guided Surgery: Molecules, Devices, and Applications IX 2023 - San Francisco, United States
Duur: 28-jan.-202329-jan.-2023

Publicatie series

NaamProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN van geprinte versie1605-7422


ConferenceMolecular-Guided Surgery: Molecules, Devices, and Applications IX 2023
Land/RegioUnited States
StadSan Francisco

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