Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography

Wejdan M Arif, Philip H Elsinga, Carmen Gasca-Salas, Michel Versluis, Raaúl Martínez-Fernández, Rudi A J O Dierckx, Ronald J H Borra, Gert Luurtsema*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

34 Citaten (Scopus)
86 Downloads (Pure)


Focused ultrasound (FUS) is a minimally-invasive technology used for treatment of many diseases, including diseases related to the colon, uterus, prostate, and brain. Although it has been mainly used for ablative procedures, the ability of FUS to open the blood-brain barrier (BBB) presents a promising new application. However, the mechanism of BBB opening by FUS remains unclear. This review focuses on the use of FUS to open the BBB for enhancing drug delivery and investigating how Positron Emission Tomography (PET) provides insight into the underlying mechanism.
Originele taal-2English
Pagina's (van-tot)303-316
Aantal pagina's14
TijdschriftJournal of controlled release : official journal of the Controlled Release Society
Vroegere onlinedatum16-mei-2020
StatusPublished - 10-aug.-2020

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