Folic acid conjugates of a bleomycin mimic for selective targeting of folate receptor positive cancer cells

Arjan Geersing, Reinder H de Vries, Gerrit Jansen, Marianne G Rots, Gerard Roelfes

OnderzoeksoutputAcademicpeer review

10 Citaten (Scopus)
103 Downloads (Pure)

Samenvatting

A major challenge in the application of cytotoxic anti-cancer drugs is their general lack of selectivity, which often leads to systematic toxicity due to their inability to discriminate between malignant and healthy cells. A particularly promising target for selective targeting are the folate receptors (FR) that are often over-expressed on cancer cells. Here, we report on a conjugate of the pentadentate nitrogen ligand N4Py to folic acid, via a cleavable disulphide linker, which shows selective cytotoxicity against folate receptor expressing cancer cells.

Originele taal-2English
Pagina's (van-tot)1922-1927
Aantal pagina's6
TijdschriftBioorganic & Medicinal Chemistry Letters
Volume29
Nummer van het tijdschrift15
DOI's
StatusPublished - 1-aug-2019

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