Functional connectome differences in individuals with hallucinations across the psychosis continuum

Maya J. L. Schutte; Marc M. Bohlken; Guusje Collin; Lucija Abramovic; Marco P. M. Boks; Wiepke Cahn; Meenakshi Dauwan; Edwin van Dellen; Neeltje E. M. van Haren; Kenneth Hugdahl; Sanne Koops; Rene C. W. Mandl; Iris E. C. Sommer

doi:10.1038/s41598-020-80657-8

Functional connectome differences in individuals with hallucinations across the psychosis continuum

Maya J. L. Schutte^*, Marc M. Bohlken, Guusje Collin, Lucija Abramovic, Marco P. M. Boks, Wiepke Cahn, Meenakshi Dauwan, Edwin van Dellen, Neeltje E. M. van Haren, Kenneth Hugdahl, Sanne Koops, Rene C. W. Mandl, Iris E. C. Sommer

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P

Originele taal-2	English
Artikelnummer	1108
Aantal pagina's	13
Tijdschrift	Scientific Reports
Volume	11
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1038/s41598-020-80657-8
Status	Published - 13-jan.-2021

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10.1038/s41598-020-80657-8Licentie: CC BY

Functional connectome differences in individuals with hallucinations across the psychosis continuumFinal publisher's version, 3,52 MBLicentie: CC BY

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Schutte, M. J. L., Bohlken, M. M., Collin, G., Abramovic, L., Boks, M. P. M., Cahn, W., Dauwan, M., van Dellen, E., van Haren, N. E. M., Hugdahl, K., Koops, S., Mandl, R. C. W., & Sommer, I. E. C. (2021). Functional connectome differences in individuals with hallucinations across the psychosis continuum. Scientific Reports, 11(1), Artikel 1108. https://doi.org/10.1038/s41598-020-80657-8

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abstract = "Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P",

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AU - Abramovic, Lucija

AU - Boks, Marco P. M.

AU - Cahn, Wiepke

AU - Dauwan, Meenakshi

AU - van Dellen, Edwin

AU - van Haren, Neeltje E. M.

AU - Hugdahl, Kenneth

AU - Koops, Sanne

AU - Mandl, Rene C. W.

AU - Sommer, Iris E. C.

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N2 - Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P

AB - Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P

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Functional connectome differences in individuals with hallucinations across the psychosis continuum

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