Functional connectome differences in individuals with hallucinations across the psychosis continuum

Maya J. L. Schutte*, Marc M. Bohlken, Guusje Collin, Lucija Abramovic, Marco P. M. Boks, Wiepke Cahn, Meenakshi Dauwan, Edwin van Dellen, Neeltje E. M. van Haren, Kenneth Hugdahl, Sanne Koops, Rene C. W. Mandl, Iris E. C. Sommer

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

4 Downloads (Pure)


Hallucinations may arise from an imbalance between sensory and higher cognitive brain regions, reflected by alterations in functional connectivity. It is unknown whether hallucinations across the psychosis continuum exhibit similar alterations in functional connectivity, suggesting a common neural mechanism, or whether different mechanisms link to hallucinations across phenotypes. We acquired resting-state functional MRI scans of 483 participants, including 40 non-clinical individuals with hallucinations, 99 schizophrenia patients with hallucinations, 74 bipolar-I disorder patients with hallucinations, 42 bipolar-I disorder patients without hallucinations, and 228 healthy controls. The weighted connectivity matrices were compared using network-based statistics. Non-clinical individuals with hallucinations and schizophrenia patients with hallucinations exhibited increased connectivity, mainly among fronto-temporal and fronto-insula/cingulate areas compared to controls (P

Originele taal-2English
Aantal pagina's13
TijdschriftScientific Reports
Nummer van het tijdschrift1
StatusPublished - 13-jan-2021

Citeer dit