Functional impairments at school age of preterm born children with late-onset sepsis

Meike van der Ree, Jozien C. Tanis, Koenraad N. J. A. Van Braeckel, Arend F. Bos, Elise Roze*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

30 Citaten (Scopus)
25 Downloads (Pure)


Background: Late-onset sepsis is a relatively common complication particularly of preterm birth that affects approximately a quarter of very low birth weight infants.

Aim: We aimed to determine the motor, cognitive, and behavioural outcome at school age of preterm children with late-onset sepsis compared to matched controls.

Study design and subjects: A prospective case-control study that included preterm infants (gestational age

Outcome measures: At school age we assessed motor skills, intelligence, visual perception, visuomotor integration, verbal memory, attention, executive functioning, and behaviour.

Results: At 6-9 years, 21 of 32 children with late-onset sepsis (68%) had borderline or abnormal motor outcome with most problems in fine motor skills. Their total IQ was 89 compared to 98 in controls. In addition, verbal memory and attention were affected compared to controls (0.61 standard deviations (SD), 95% confidence interval (Cl) 0.04-1.17, p = 0.033 and 0.94 SD, 95% Cl 0.32-1.62, p = 0.011, respectively). Multiple episodes of sepsis and gram-negative sepsis were risk factors for worse cognitive outcome.

Conclusions: At school age, a majority of preterm children with late-onset sepsis had motor problems. Their IQ was considerably lower than matched controls, and memory and attention were specifically impaired. Outcome at school age of preterm children with late-onset sepsis was worse than previously thought. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)821-826
Aantal pagina's6
TijdschriftEarly Human Development
Nummer van het tijdschrift12
StatusPublished - dec-2011

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