Functional respiratory imaging: Heterogeneity of acute exacerbations of COPD

Wouter H. van Geffen*, Bita Hajian, Wim Vos, Jan De Backer, Anthony Cahn, Omar Susmani, Cedric Van Holsbeke, Massimo Pistolesi, Huib A. M. Kerstjens, Wilfried De Backer

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

11 Citaten (Scopus)
360 Downloads (Pure)

Samenvatting

Background: Exacerbations of COPD are a major burden to patients, and yet little is understood about heterogeneity. It contributes to the current persistent one-size-fits-all treatment. To replace this treatment by more personalized, precision medicine, new insights are required. We assessed the heterogeneity of exacerbations by functional respiratory imaging (FRI) in 3-dimensional models of airways and lungs.

Methods: The trial was designed as a multicenter trial of patients with an acute exacerbation of COPD who were assessed by FRI, pulmonary function tests, and patient-reported outcomes, both in the acute stage and during resolution.

Results: Forty seven patients were assessed. FRI analyses showed significant improvements in hyperinflation (a decrease in total volume at functional residual capacity of -0.25 +/- 0.61 L, p

Conclusion: FRI is a useful tool to get a better insight into exacerbations of COPD, and significant improvements in its indices can be demonstrated from the acute phase to resolution even in relatively small groups. It clearly visualizes the marked variability within and between individuals in ventilation and resistance during exacerbations and is a tool for the assessment of the heterogeneity of COPD exacerbations.

Originele taal-2English
Pagina's (van-tot)1783-1792
Aantal pagina's10
TijdschriftInternational Journal of Chronic Obstructive Pulmonary Disease
Volume13
DOI's
StatusPublished - 30-mei-2018

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