Future perspective for the application of predictive biomarker testing in advanced stage non-small cell lung cancer

Vincent D de Jager, Wim Timens, Arnaud Bayle, Johan Botling, Luka Brcic, Reinhard Büttner, Maria Gabriela O Fernandes, Libor Havel, Maximilian Hochmair, Paul Hofman, Annelies Janssens, Léon van Kempen, Izidor Kern, José Carlos Machado, Katja Mohorčič, Sanjay Popat, Aleš Ryška, Jürgen Wolf, Ed Schuuring*, Anthonie J van der Wekken*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

7 Citaten (Scopus)
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Samenvatting

For patients with advanced stage non-small cell lung cancer (NSCLC), treatment strategies have changed significantly due to the introduction of targeted therapies and immunotherapy. In the last few years, we have seen an explosive growth of newly introduced targeted therapies in oncology and this development is expected to continue in the future. Besides primary targetable aberrations, emerging diagnostic biomarkers also include relevant co-occurring mutations and resistance mechanisms involved in disease progression, that have impact on optimal treatment management. To accommodate testing of pending biomarkers, it is necessary to establish routine large-panel next-generation sequencing (NGS) for all patients with advanced stage NSCLC. For cost-effectiveness and accessibility, it is recommended to implement predictive molecular testing using large-panel NGS in a dedicated, centralized expert laboratory within a regional oncology network. The central molecular testing center should host a regional Molecular Tumor Board and function as a hub for interpretation of rare and complex testing results and clinical decision-making.

Originele taal-2English
Artikelnummer100839
Aantal pagina's9
TijdschriftThe Lancet Regional Health - Europe
Volume38
DOI's
StatusPublished - mrt.-2024

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