Galectin-3 and sST2 in prediction of left ventricular ejection fraction after myocardial infarction

A. Rogier van der Velde, Chris P. H. Lexis, Wouter C. Meijers, Iwan C. van der Horst, Erik Lipsic, Martin M. Dokter, Dirk J. van Veldhuisen, Pim van der Harst, Rudolf A. de Boer*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

24 Citaten (Scopus)

Samenvatting

Background: Fibrosis is a pivotal event in infarct repair and progressive remodeling after myocardial infarction (MI). Biomarkers may be used to monitor fibrosis, and therefore we evaluated the predictive value of galectin-3 and sST2 for cardiac remodeling after MI.

Methods: Plasma galectin-3 and sST2 were measured in patients admitted with primary percutaneous coronary intervention (PCI) for acute MI, at baseline and at 4 months. Left ventricular ejection fraction (LVEF) and infarct size were measured after 4 months with cardiac MRI (CMR).

Results: In total, 247 patients had blood samples and CMR data available (mean age 57.7 +/- 11.6 years; 79.8% male). Increased baseline galectin-3 (>= 17.8 ng/mL) identified patients with lower LVEF (503% (+/- 9.1) vs. non elevated galectin-3 55.0% (+/- 8.0); P <0.001), and larger infarct size (13.8 g. (+/- 12.9) vs. 8.6 g. (+/- 8.7); P = 0.002) after 4 months. Elevated sST2 (>= 35.0 ng/mL) did not predict decreased LVEF or larger infarct size. Furthermore we showed that at baseline, galectin-3 was an independent predictor for LVEF (beta = -0.18; P = 0.005) and infarct size (beta = 0.18; P = 0.004). We repeated the analyses using median values of galectin-3 (13.4 ng/mL) and sST2 (303 ng/mL) as a cut point, and this validated our results.

Conclusion: The fibrosis biomarker galectin-3, but not sST2, taken immediately after MI, predicts LVEF and infarct size after 4 months. We hypothesize that galectin-3 may play a role in the pathophysiology of cardiac remodeling after acute MI. (C) 2015 Elsevier B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)50-57
Aantal pagina's8
TijdschriftClinica chimica acta
Volume452
DOI's
StatusPublished - 15-jan-2016

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