Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

Jingyue Jia, Aurore Claude-Taupin, Yuexi Gu, Seong Won Choi, Ryan Peters, Bhawana Bissa, Michal H. Mudd, Lee Allers, Sandeep Pallikkuth, Keith A. Lidke, Michelle Salemi, Brett Phinney, Muriel Mari, Fulvio Reggiori, Vojo Deretic*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

95 Citaten (Scopus)
46 Downloads (Pure)

Samenvatting

Jia et al. show that Galectin-3 recruits ESCRT components to damaged lysosomes for repair and restoration of their function. During sustained lysosomal injury, galectins induce autophagy and lysosomal biogenesis for a staged repair, removal, and replacement program. This response is deployed during damage with neurotoxic tau or Mycobacterium tuberculosis infection.

Originele taal-2English
Pagina's (van-tot)69-+
Aantal pagina's27
TijdschriftDevelopmental Cell
Volume52
Nummer van het tijdschrift1
Vroegere onlinedatum29-nov-2019
DOI's
StatusPublished - 6-jan-2020

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