Galectin-3 in Heart Failure: An Update of the Last 3 Years

Carolin Gehlken, Navin Suthahar, Wouter C. Meijers, Rudolf A. de Boer*

*Bijbehorende auteur voor dit werk

Onderzoeksoutputpeer review

88 Citaten (Scopus)
105 Downloads (Pure)

Samenvatting

Galectin-3 plays a role in tissue inflammation, repair, and fibrosis. This article specifically focuses on heart failure (HF), in which galectin-3 has been shown to be a useful biomarker in prognosis and risk stratification, especially in HF with preserved ejection fraction. Experimental research has shown that galectin-3 directly induces pathologic remodeling of the heart, and is therefore considered a culprit protein in the development of cardiac fibrosis in HF, with potentially relevant clinical implications. In summary, galectin-3 is a biomarker and biotarget in cardiac remodeling and fibrosis and future research will target galectin-3-centered diseases.

Originele taal-2English
Pagina's (van-tot)75-92
Aantal pagina's18
TijdschriftHeart failure clinics
Volume14
Nummer van het tijdschrift1
DOI's
StatusPublished - jan.-2018

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