TY - JOUR
T1 - Generating New Blood Flow
T2 - Integrating Developmental Biology and Tissue Engineering
AU - Krenning, Guido
AU - Moonen, Jan-Renier A. J.
AU - van Luyn, Marja J. A.
AU - Harmsen, Martin C.
PY - 2008/11
Y1 - 2008/11
N2 - Vascular tissue engineering aims to restore blood flow by seeding artificial tubular scaffolds with endothelial and smooth muscle cells, thus creating bioartificial blood vessels. Herein, the progenitors of smooth muscle and endothelial cells hold great promise because they efficiently differentiate and harbor longevity. In this review, we describe a novel tissue engineering approach that uses current insights from developmental biology, that is, progenitor cell plasticity, and the latest advances in biomaterial design. We focus specifically on developmental processes that regulate progenitor cell (trans)differentiation and offer a platform for the integration of these molecular clues into biomaterial design. We propose a novel engineering paradigm for the creation of a small-diameter blood vessel wherein progenitor cell differentiation and tissue organization are instructed by the biomaterial solely. With this review, we emphasize the power of integrating developmental biology and material science for vascular tissue engineering. (Trends Cardiovasc Med 2008;18:312-323) (C) 2008, Elsevier Inc.
AB - Vascular tissue engineering aims to restore blood flow by seeding artificial tubular scaffolds with endothelial and smooth muscle cells, thus creating bioartificial blood vessels. Herein, the progenitors of smooth muscle and endothelial cells hold great promise because they efficiently differentiate and harbor longevity. In this review, we describe a novel tissue engineering approach that uses current insights from developmental biology, that is, progenitor cell plasticity, and the latest advances in biomaterial design. We focus specifically on developmental processes that regulate progenitor cell (trans)differentiation and offer a platform for the integration of these molecular clues into biomaterial design. We propose a novel engineering paradigm for the creation of a small-diameter blood vessel wherein progenitor cell differentiation and tissue organization are instructed by the biomaterial solely. With this review, we emphasize the power of integrating developmental biology and material science for vascular tissue engineering. (Trends Cardiovasc Med 2008;18:312-323) (C) 2008, Elsevier Inc.
KW - ENDOTHELIAL PROGENITOR CELLS
KW - SMOOTH-MUSCLE-CELLS
KW - EPITHELIAL-MESENCHYMAL TRANSFORMATION
KW - EMBRYONIC STEM-CELLS
KW - GROWTH FACTOR-BB
KW - IN-VITRO
KW - MATRIX METALLOPROTEINASES
KW - EXTRACELLULAR-MATRIX
KW - PHENOTYPIC MODULATION
KW - PARACRINE MECHANISMS
M3 - Review article
SN - 1050-1738
VL - 18
SP - 312
EP - 323
JO - TRENDS IN CARDIOVASCULAR MEDICINE
JF - TRENDS IN CARDIOVASCULAR MEDICINE
IS - 8
M1 - PII S1050-1738(09)00026-7
ER -