Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility

MM de Jong, IM Nolte, GJT Meerman, WTA van der Graaf, JC Oosterwijk, JH Kleibeuker, M Schaapveld, EGE de Vries*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articleAcademicpeer review

182 Citaten (Scopus)

Samenvatting

This review focuses on genes other than the high penetrance genes BRCA1 and BRCA2 that are involved in breast cancer susceptibility. The goal of this review is the discovery of polymorphisms that are either associated with breast cancer or that are in strong linkage disequilibrium with breast cancer causing variants. An association with breast cancer at a 5% significance level was found for 13 polymorphisms in 10 genes described in more than one breast cancer study. Our data will help focus on the further analysis of genetic polymorphisms in populations of appropriate size, and especially on the combinations of such polymorphisms. This will facilitate determination of population attributable risks, understanding of gene-gene interactions, and improving estimates of genetic cancer risks.

Originele taal-2English
Pagina's (van-tot)225-242
Aantal pagina's18
TijdschriftJOURNAL OF MEDICAL GENETICS
Volume39
Nummer van het tijdschrift4
StatusPublished - apr-2002

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