Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Million Veteran Program; Evangelos Evangelou; Helen R Warren; David Mosen-Ansorena; Borbala Mifsud; Raha Pazoki; He Gao; Georgios Ntritsos; Niki Dimou; Claudia P Cabrera; Ibrahim Karaman; Fu Liang Ng; Marina Evangelou; Katarzyna Witkowska; Evan Tzanis; Jacklyn N Hellwege; Ayush Giri; Digna R Velez Edwards; Yan V Sun; Kelly Cho; J Michael Gaziano; Peter W F Wilson; Philip S Tsao; Csaba P Kovesdy; Tonu Esko; Reedik Mägi; Lili Milani; Peter Almgren; Thibaud Boutin; Stéphanie Debette; Jun Ding; Franco Giulianini; Elizabeth G Holliday; Anne U Jackson; Ruifang Li-Gao; Bram Peter Prins; Niek Verweij; Jing-Hua Zhao; Martin H de Borst; Catharina A Hartman; Li Lin; Ilja M Nolte; Albertine J Oldehinkel; Brenda W J H Penninx; Harriëtte Riese; Albert V Smith; Harold Snieder; Morris A Swertz; Ahmad Vaez; Peter J van der Most; Pim van der Harst

doi:10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Million Veteran Program, Evangelos Evangelou, Helen R Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia P Cabrera, Ibrahim Karaman, Fu Liang Ng, Marina Evangelou, Katarzyna Witkowska, Evan Tzanis, Jacklyn N Hellwege, Ayush Giri, Digna R Velez Edwards, Yan V Sun, Kelly ChoJ Michael Gaziano, Peter W F Wilson, Philip S Tsao, Csaba P Kovesdy, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Stéphanie Debette, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U Jackson, Ruifang Li-Gao, Bram Peter Prins, Niek Verweij, Jing-Hua Zhao, Martin H de Borst, Catharina A Hartman, Li Lin, Ilja M Nolte, Albertine J Oldehinkel, Brenda W J H Penninx, Harriëtte Riese, Albert V Smith, Harold Snieder, Morris A Swertz, Ahmad Vaez, Peter J van der Most, Pim van der Harst

Onderzoeksoutput › Academic › peer review

208 Citaten (Scopus)

Samenvatting

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Originele taal-2	English
Pagina's (van-tot)	1412-+
Aantal pagina's	17
Tijdschrift	Nature Genetics
Volume	50
Nummer van het tijdschrift	10
Vroegere onlinedatum	17-sep-2018
DOI's	https://doi.org/10.1038/s41588-018-0205-x
Status	Published - okt-2018

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10.1038/s41588-018-0205-x

https://helda.helsinki.fi/bitstream/handle/10138/251517/s41588_018_0205_x.pdf?sequence=1Licentie: Unspecified

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
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Million Veteran Program, Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., ... van der Harst, P. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50(10), 1412-+. https://doi.org/10.1038/s41588-018-0205-x

Million Veteran Program ; Evangelou, Evangelos ; Warren, Helen R ; Mosen-Ansorena, David ; Mifsud, Borbala ; Pazoki, Raha ; Gao, He ; Ntritsos, Georgios ; Dimou, Niki ; Cabrera, Claudia P ; Karaman, Ibrahim ; Ng, Fu Liang ; Evangelou, Marina ; Witkowska, Katarzyna ; Tzanis, Evan ; Hellwege, Jacklyn N ; Giri, Ayush ; Velez Edwards, Digna R ; Sun, Yan V ; Cho, Kelly ; Gaziano, J Michael ; Wilson, Peter W F ; Tsao, Philip S ; Kovesdy, Csaba P ; Esko, Tonu ; Mägi, Reedik ; Milani, Lili ; Almgren, Peter ; Boutin, Thibaud ; Debette, Stéphanie ; Ding, Jun ; Giulianini, Franco ; Holliday, Elizabeth G ; Jackson, Anne U ; Li-Gao, Ruifang ; Prins, Bram Peter ; Verweij, Niek ; Zhao, Jing-Hua ; Borst, Martin H de ; Hartman, Catharina A ; Lin, Li ; Nolte, Ilja M ; Oldehinkel, Albertine J ; Penninx, Brenda W J H ; Riese, Harriëtte ; Smith, Albert V ; Snieder, Harold ; Swertz, Morris A ; Vaez, Ahmad ; van der Most, Peter J ; van der Harst, Pim. / Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. In: Nature Genetics. 2018 ; Vol. 50, Nr. 10. blz. 1412-+.

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Million Veteran Program, Evangelou, E, Warren, HR, Mosen-Ansorena, D, Mifsud, B, Pazoki, R, Gao, H, Ntritsos, G, Dimou, N, Cabrera, CP, Karaman, I, Ng, FL, Evangelou, M, Witkowska, K, Tzanis, E, Hellwege, JN, Giri, A, Velez Edwards, DR, Sun, YV, Cho, K, Gaziano, JM, Wilson, PWF, Tsao, PS, Kovesdy, CP, Esko, T, Mägi, R, Milani, L, Almgren, P, Boutin, T, Debette, S, Ding, J, Giulianini, F, Holliday, EG, Jackson, AU, Li-Gao, R, Prins, BP, Verweij, N, Zhao, J-H, Borst, MHD , Hartman, CA, Lin, L, Nolte, IM , Oldehinkel, AJ, Penninx, BWJH, Riese, H, Smith, AV, Snieder, H , Swertz, MA , Vaez, A , van der Most, PJ & van der Harst, P 2018, 'Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits', Nature Genetics, vol. 50, nr. 10, blz. 1412-+. https://doi.org/10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. / Million Veteran Program; Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael; Wilson, Peter W F; Tsao, Philip S; Kovesdy, Csaba P; Esko, Tonu; Mägi, Reedik; Milani, Lili; Almgren, Peter; Boutin, Thibaud; Debette, Stéphanie; Ding, Jun; Giulianini, Franco; Holliday, Elizabeth G; Jackson, Anne U; Li-Gao, Ruifang; Prins, Bram Peter; Verweij, Niek; Zhao, Jing-Hua; Borst, Martin H de ; Hartman, Catharina A; Lin, Li; Nolte, Ilja M ; Oldehinkel, Albertine J; Penninx, Brenda W J H; Riese, Harriëtte; Smith, Albert V; Snieder, Harold ; Swertz, Morris A ; Vaez, Ahmad ; van der Most, Peter J ; van der Harst, Pim.

In: Nature Genetics, Vol. 50, Nr. 10, 10.2018, blz. 1412-+.

Onderzoeksoutput › Academic › peer review

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T1 - Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

AU - Million Veteran Program

AU - Evangelou, Evangelos

AU - Warren, Helen R

AU - Mosen-Ansorena, David

AU - Mifsud, Borbala

AU - Pazoki, Raha

AU - Gao, He

AU - Ntritsos, Georgios

AU - Dimou, Niki

AU - Cabrera, Claudia P

AU - Karaman, Ibrahim

AU - Ng, Fu Liang

AU - Evangelou, Marina

AU - Witkowska, Katarzyna

AU - Tzanis, Evan

AU - Hellwege, Jacklyn N

AU - Giri, Ayush

AU - Velez Edwards, Digna R

AU - Sun, Yan V

AU - Cho, Kelly

AU - Gaziano, J Michael

AU - Wilson, Peter W F

AU - Tsao, Philip S

AU - Kovesdy, Csaba P

AU - Esko, Tonu

AU - Mägi, Reedik

AU - Milani, Lili

AU - Almgren, Peter

AU - Boutin, Thibaud

AU - Debette, Stéphanie

AU - Ding, Jun

AU - Giulianini, Franco

AU - Holliday, Elizabeth G

AU - Jackson, Anne U

AU - Li-Gao, Ruifang

AU - Prins, Bram Peter

AU - Verweij, Niek

AU - Zhao, Jing-Hua

AU - Borst, Martin H de

AU - Hartman, Catharina A

AU - Lin, Li

AU - Nolte, Ilja M

AU - Oldehinkel, Albertine J

AU - Penninx, Brenda W J H

AU - Riese, Harriëtte

AU - Smith, Albert V

AU - Snieder, Harold

AU - Swertz, Morris A

AU - Vaez, Ahmad

AU - van der Most, Peter J

AU - van der Harst, Pim

PY - 2018/10

Y1 - 2018/10

N2 - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

AB - High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

KW - GENOME-WIDE ASSOCIATION

KW - CARDIOVASCULAR-DISEASE RISK

KW - UK BIOBANK

KW - HYPERTENSION

KW - VARIANTS

KW - METAANALYSIS

KW - COMMON

KW - HEALTH

KW - RARE

KW - HYPERALDOSTERONISM

U2 - 10.1038/s41588-018-0205-x

DO - 10.1038/s41588-018-0205-x

M3 - Article

C2 - 30224653

VL - 50

SP - 1412-+

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

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ER -