@article{1a3fe681ae6c451698e97e7b01c6ad6f,
title = "Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits",
abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.",
keywords = "GENOME-WIDE ASSOCIATION, CARDIOVASCULAR-DISEASE RISK, UK BIOBANK, HYPERTENSION, VARIANTS, METAANALYSIS, COMMON, HEALTH, RARE, HYPERALDOSTERONISM",
author = "\{Million Veteran Program\} and Evangelos Evangelou and Warren, \{Helen R\} and David Mosen-Ansorena and Borbala Mifsud and Raha Pazoki and He Gao and Georgios Ntritsos and Niki Dimou and Cabrera, \{Claudia P\} and Ibrahim Karaman and Ng, \{Fu Liang\} and Marina Evangelou and Katarzyna Witkowska and Evan Tzanis and Hellwege, \{Jacklyn N\} and Ayush Giri and \{Velez Edwards\}, \{Digna R\} and Sun, \{Yan V\} and Kelly Cho and Gaziano, \{J Michael\} and Wilson, \{Peter W F\} and Tsao, \{Philip S\} and Kovesdy, \{Csaba P\} and Tonu Esko and Reedik M{\"a}gi and Lili Milani and Peter Almgren and Thibaud Boutin and St{\'e}phanie Debette and Jun Ding and Franco Giulianini and Holliday, \{Elizabeth G\} and Jackson, \{Anne U\} and Ruifang Li-Gao and Prins, \{Bram Peter\} and Niek Verweij and Jing-Hua Zhao and Borst, \{Martin H de\} and Hartman, \{Catharina A\} and Li Lin and Nolte, \{Ilja M\} and Oldehinkel, \{Albertine J\} and Penninx, \{Brenda W J H\} and Harri{\"e}tte Riese and Smith, \{Albert V\} and Harold Snieder and Swertz, \{Morris A\} and Ahmad Vaez and \{van der Most\}, \{Peter J\} and \{van der Harst\}, Pim",
year = "2018",
month = oct,
doi = "10.1038/s41588-018-0205-x",
language = "English",
volume = "50",
pages = "1412--+",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "10",
}