Genetic and Environmental Determinants of Respiratory Health

Xiang Zeng

Genetic and Environmental Determinants of Respiratory Health

Xiang Zeng

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Luchtweg gerelateerde symptomen en een verminderde longfunctie zijn kenmerken van luchtwegziekten. Echter, de mechanismes zijn nog onduidelijk. Luchtweg gerelateerde symptomen kunnen veroorzaakt worden door verschillende omgevingsblootstellingen of het kan een vertoon zijn van verschillende onderliggende ziekten met een specifieke genetische of omgevingsoorsprong. Het doel van dit promotieonderzoek is om te onderzoeken of omgevingsblootstellingen geassocieerd zijn het niveau van longfunctie en de prevalentie van luchtweg gerelateerde symptomen, en om na te gaan of de effecten van deze blootstellingen afhankelijk zijn van de genetische make-up met behulp van een Chinese kinderen cohort en twee Nederlandse volwassen cohorten (LifeLines en Vlagtwedde-Vlaardingen cohorten). Het wonen in e-wast blootgestelde gebieden heeft nadelige gevolgen, zoals een hogere prevalentie van luchtweg gerelateerde symptomen en een verminderde longfunctie in Chinese kleuters. Volgens een genoom-brede interactie analyse (GWIS) en expressie quantitative trait loci (eQTL), zijn verscheidene SNPs in de genen TMPRSS9, TOX3 en ARHGAP18 geassocieerd met zowel één van de luchtweg gerelateerde symptomen in personen met een beroepsmatige blootstelling en genexpressie niveaus. SNPs die in de genen ROCK2, GLS en KCTD10 liggen zijn geassocieerd met één van de luchtweg gerelateerde symptomen in de SNP-bij-NO2 interactie analyse en zijn eQTLs. Deze informatie kan bijdragen aan de kennis van de mechanismes (pathways) die betrokken zijn bij het ontwikkelen van luchtweg gerelateerde symptomen en bij de identificatie van personen die een verhoogde genetische gevoeligheid hebben voor omgevingsblootstellingen.

Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Boezen, Hendrika M., Supervisor Huo, Xia, Supervisor, Externe Persoon Vonk, Judith, Co-supervisor
Datum van toekenning	12-okt.-2016
Plaats van publicatie	[Groningen]
Uitgever	University of Groningen
Gedrukte ISBN's	978-90-367-9201-1
Elektronische ISBN's	978-90-367-9200-4
Status	Published - 2016

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Title and contents Final publisher's version, 218 KB
Chapter 1 Final publisher's version, 404 KB
Chapter 2 Final publisher's version, 411 KB
Chapter 3 Final publisher's version, 360 KB
Chapter 4 Final publisher's version, 302 KB
Chapter 5 Final publisher's version, 183 KB
Chapter 6 Final publisher's version, 640 KB
Chapter 7 Final publisher's version, 279 KB
Chapter 8 Final publisher's version, 331 KB
Chapter 9 Final publisher's version, 223 KB
Complete thesisFinal publisher's version, 2,21 MB
PropositionsFinal publisher's version, 106 KB

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Permanente koppeling

Lifelines Biobank
Bakker, S. (Creator), Dotinga, A. (Creator), Vonk, J. M. (Creator), Smidt, N. (Creator), Scholtens, S. (Creator), Swertz, M. (Creator), Wijmenga, C. (Creator), Wolffenbutel, B. H. (Creator), Stolk, R. (Creator), van Zon, S. (Creator), Rosmalen, J. (Creator), Postma, D. S. (Creator), de Boer, R. (Creator), Navis, G. (Creator), Slaets, J. (Creator), Ormel, J. (Creator), van Dijk, F. (Creator) & Bolmer, B. (Data Manager), Lifelines, 2006
https://www.lifelines.nl/ en nog één link, https://catalogue.lifelines.nl/ (minder tonen)
Dataset
Vlagtwedde-Vlaardingen Study (VlaVla)
Wijbenga, J. (Other), Boezen, H. M. (Creator) & VANDERLENDE, R. (Creator), University of Groningen, 1990
https://www.umcg.nl/EN/Research/Researchers/Facilities/biobanks/biobanks/Vlagtwedde-Vlaardingen/paginas/default.aspx en nog één link, https://kennisinzicht.umcg.nl/Paginas/Een-scala-aan-tests-en-prikjes.aspx (minder tonen)
Dataset

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title = "Genetic and Environmental Determinants of Respiratory Health",

abstract = "Respiratory symptoms and low levels of lung function are main characteristics of respiratory diseases. However, their mechanisms are still unclear. Respiratory symptom can be caused by different environmental exposures or can be a presentation of different underlying diseases with specific genetic or environmental origins. The aim of this thesis is to assess whether environmental exposures are associated with the levels of lung function and respiratory symptoms, and to examine whether the effects of these exposures are dependent on genetic make-up using one Chinese children and two Dutch adult cohort studies (LifeLines and Vlagtwedde-Vlaardingen cohorts). Living in e-waste exposed areas have adverse effects such as higher prevalence of respiratory symptoms and lower levels of lung function on Chinese preschool children. According to genome-wide interaction analysis (GWIS) and expression quantitative trait loci (eQTLs), several SNPs located on TMPRSS9, TOX3, and ARHGAP18 are associated with both one of the respiratory symptoms in subjects with occupational exposures and gene expression levels. SNPs located on ROCK2, GLS and KCTD10 have been found to be associated with one of the respiratory symptoms on SNP-by-NO2 interaction analysis and eQTLs. This information may contribute to the understanding of pathways underlying the development of respiratory symptoms and to the identification of subjects that are genetically susceptible to environmental exposures.",

author = "Xiang Zeng",

year = "2016",

language = "English",

isbn = "978-90-367-9201-1",

publisher = "University of Groningen",

school = "University of Groningen",

}

TY - BOOK

T1 - Genetic and Environmental Determinants of Respiratory Health

AU - Zeng, Xiang

PY - 2016

Y1 - 2016

N2 - Respiratory symptoms and low levels of lung function are main characteristics of respiratory diseases. However, their mechanisms are still unclear. Respiratory symptom can be caused by different environmental exposures or can be a presentation of different underlying diseases with specific genetic or environmental origins. The aim of this thesis is to assess whether environmental exposures are associated with the levels of lung function and respiratory symptoms, and to examine whether the effects of these exposures are dependent on genetic make-up using one Chinese children and two Dutch adult cohort studies (LifeLines and Vlagtwedde-Vlaardingen cohorts). Living in e-waste exposed areas have adverse effects such as higher prevalence of respiratory symptoms and lower levels of lung function on Chinese preschool children. According to genome-wide interaction analysis (GWIS) and expression quantitative trait loci (eQTLs), several SNPs located on TMPRSS9, TOX3, and ARHGAP18 are associated with both one of the respiratory symptoms in subjects with occupational exposures and gene expression levels. SNPs located on ROCK2, GLS and KCTD10 have been found to be associated with one of the respiratory symptoms on SNP-by-NO2 interaction analysis and eQTLs. This information may contribute to the understanding of pathways underlying the development of respiratory symptoms and to the identification of subjects that are genetically susceptible to environmental exposures.

AB - Respiratory symptoms and low levels of lung function are main characteristics of respiratory diseases. However, their mechanisms are still unclear. Respiratory symptom can be caused by different environmental exposures or can be a presentation of different underlying diseases with specific genetic or environmental origins. The aim of this thesis is to assess whether environmental exposures are associated with the levels of lung function and respiratory symptoms, and to examine whether the effects of these exposures are dependent on genetic make-up using one Chinese children and two Dutch adult cohort studies (LifeLines and Vlagtwedde-Vlaardingen cohorts). Living in e-waste exposed areas have adverse effects such as higher prevalence of respiratory symptoms and lower levels of lung function on Chinese preschool children. According to genome-wide interaction analysis (GWIS) and expression quantitative trait loci (eQTLs), several SNPs located on TMPRSS9, TOX3, and ARHGAP18 are associated with both one of the respiratory symptoms in subjects with occupational exposures and gene expression levels. SNPs located on ROCK2, GLS and KCTD10 have been found to be associated with one of the respiratory symptoms on SNP-by-NO2 interaction analysis and eQTLs. This information may contribute to the understanding of pathways underlying the development of respiratory symptoms and to the identification of subjects that are genetically susceptible to environmental exposures.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-9201-1

PB - University of Groningen

CY - [Groningen]

ER -

Genetic and Environmental Determinants of Respiratory Health

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Datasets

Lifelines Biobank

Vlagtwedde-Vlaardingen Study (VlaVla)

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