Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Lianmin Chen, Kiki Schraa, Inge C L van den Munckhof, Rob Ter Horst, Martijn Koehorst, Martijn van Faassen, Claude van der Ley, Marwah Doestzada, Daria V Zhernakova, Alexander Kurilshikov, Vincent W Bloks, Albert K Groen, Human Functional Genomics Project, Niels P Riksen, Joost H W Rutten, Leo A B Joosten, Cisca Wijmenga, Alexandra Zhernakova, Mihai G Netea, Jingyuan FuFolkert Kuipers

OnderzoeksoutputAcademicpeer review

4 Citaten (Scopus)
34 Downloads (Pure)

Samenvatting

Bile acids (BAs) have been implicated in obesity-related conditions such as NAFLD and hyperlipidemia. Different human BAs exert variable biological activities. Chen et al. define genetic and microbial associations to plasma and fecal BA concentrations and composition in persons with obesity and establish their relationships with liver fat and lipid phenotypes.

Originele taal-2English
Artikelnummer108212
Aantal pagina's13
TijdschriftCell reports
Volume33
Nummer van het tijdschrift1
DOI's
StatusPublished - 6-okt-2020

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