Genetic aspects of atrial fibrillation

ACP Wiesfeld; MEW Hemels; JP Van Tintelen; MP Van den Berg; DJ Van Veldhuisen; IC Van Gelder

doi:10.1016/j.cardiores.2005.04.033

Genetic aspects of atrial fibrillation

ACP Wiesfeld, MEW Hemels, JP Van Tintelen, MP Van den Berg, DJ Van Veldhuisen, IC Van Gelder^*

^*Corresponding author voor dit werk

Cardiovasculair Centrum

Onderzoeksoutput › peer review

15 Citaten (Scopus)

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Atrial fibrillation (AF) occurs predominantly in the elderly and is commonly associated with underlying cardiac diseases. A significant number of patients, however, have early onset AF that is not associated with any underlying disease. At present, it is unknown how often this form of AF is familial and how frequently familial AF is due to genetic causes. Recent data suggest that familial AF occurs more frequently than previously recognized. Also, in AF in the setting of underlying diseases, it is suggested that some form of genetic control may be present. Understanding the molecular mechanisms underlying AF may provide insight into the pathogenesis of AF and eventually may lead to improved, patient-tailored rhythm control strategies. (C) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

Originele taal-2	English
Pagina's (van-tot)	414-418
Aantal pagina's	5
Tijdschrift	Cardiovascular Research
Volume	67
Nummer van het tijdschrift	3
DOI's	https://doi.org/10.1016/j.cardiores.2005.04.033
Status	Published - 15-aug.-2005

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@article{cf2cb569a9704628929ecfd86055e8df,

title = "Genetic aspects of atrial fibrillation",

abstract = "Atrial fibrillation (AF) occurs predominantly in the elderly and is commonly associated with underlying cardiac diseases. A significant number of patients, however, have early onset AF that is not associated with any underlying disease. At present, it is unknown how often this form of AF is familial and how frequently familial AF is due to genetic causes. Recent data suggest that familial AF occurs more frequently than previously recognized. Also, in AF in the setting of underlying diseases, it is suggested that some form of genetic control may be present. Understanding the molecular mechanisms underlying AF may provide insight into the pathogenesis of AF and eventually may lead to improved, patient-tailored rhythm control strategies. (C) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.",

keywords = "arrhythmia (mechanisms), gene expression, gene polymorphisms, supraventricular arrythmia, DOMINANT DILATED CARDIOMYOPATHY, OF-FUNCTION MUTATION, RISK-FACTOR, LOCUS, KCNQ1, IDENTIFICATION, POLYMORPHISMS, ASSOCIATION, ARRHYTHMIAS, MECHANISM",

author = "ACP Wiesfeld and MEW Hemels and {Van Tintelen}, JP and {Van den Berg}, MP and {Van Veldhuisen}, DJ and {Van Gelder}, IC",

year = "2005",

month = aug,

day = "15",

doi = "10.1016/j.cardiores.2005.04.033",

language = "English",

volume = "67",

pages = "414--418",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Genetic aspects of atrial fibrillation

AU - Wiesfeld, ACP

AU - Hemels, MEW

AU - Van Tintelen, JP

AU - Van den Berg, MP

AU - Van Veldhuisen, DJ

AU - Van Gelder, IC

PY - 2005/8/15

Y1 - 2005/8/15

N2 - Atrial fibrillation (AF) occurs predominantly in the elderly and is commonly associated with underlying cardiac diseases. A significant number of patients, however, have early onset AF that is not associated with any underlying disease. At present, it is unknown how often this form of AF is familial and how frequently familial AF is due to genetic causes. Recent data suggest that familial AF occurs more frequently than previously recognized. Also, in AF in the setting of underlying diseases, it is suggested that some form of genetic control may be present. Understanding the molecular mechanisms underlying AF may provide insight into the pathogenesis of AF and eventually may lead to improved, patient-tailored rhythm control strategies. (C) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

AB - Atrial fibrillation (AF) occurs predominantly in the elderly and is commonly associated with underlying cardiac diseases. A significant number of patients, however, have early onset AF that is not associated with any underlying disease. At present, it is unknown how often this form of AF is familial and how frequently familial AF is due to genetic causes. Recent data suggest that familial AF occurs more frequently than previously recognized. Also, in AF in the setting of underlying diseases, it is suggested that some form of genetic control may be present. Understanding the molecular mechanisms underlying AF may provide insight into the pathogenesis of AF and eventually may lead to improved, patient-tailored rhythm control strategies. (C) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

KW - arrhythmia (mechanisms)

KW - gene expression

KW - gene polymorphisms

KW - supraventricular arrythmia

KW - DOMINANT DILATED CARDIOMYOPATHY

KW - OF-FUNCTION MUTATION

KW - RISK-FACTOR

KW - LOCUS

KW - KCNQ1

KW - IDENTIFICATION

KW - POLYMORPHISMS

KW - ASSOCIATION

KW - ARRHYTHMIAS

KW - MECHANISM

U2 - 10.1016/j.cardiores.2005.04.033

DO - 10.1016/j.cardiores.2005.04.033

M3 - Review article

SN - 0008-6363

VL - 67

SP - 414

EP - 418

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 3

ER -

Genetic aspects of atrial fibrillation

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