Genetic aspects of Multiple Sclerosis

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Samenvatting

General introduction into Multiple Sclerosis (MS). Chapter 2 review of the literature on genetic epidemiology of MS with emphasis on whole genome screens. Chapter 3 Haplotype sharing, association analysis and TDT in the HLA region in MS patients. Support for a 50 kb interval containing HLA DQB1. Chapter 4: analysis of the inheritance mode of HLA-associated susceptibility: the effect is stronger than additive. Chapter 5: comparison of relapsing remitting/secondary progressive and primary progressive MS for HLA region: differences and similarities, suggesting that both types are part of a spectrum. Chapter 7 summary and conclusions, chapter 8 samenvatting.
Originele taal-2English
KwalificatieDoctor of Philosophy
Begeleider(s)/adviseur
  • Buys, Carolus, Supervisor
  • de Keyser, Jacques, Supervisor
Datum van toekenning3-jan.-0001
Plaats van publicatieGroningen
Uitgever
Gedrukte ISBN's9090202919
StatusPublished - 2006

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